Cardiac metabolism in hypertrophy and heart failure: implications for therapy

N Siddiqi, S Singh, R Beadle, D Dawson, M Frenneaux

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


The heart consumes huge amounts of energy to fulfil its function as a relentless pump. A highly sophisticated system of energy generation based on flexibility of substrate use and efficient energy production, effective energy sensing and energy transfer ensures function of the healthy heart across a range of physiological situations. In left ventricular hypertrophy and heart failure, these processes become disturbed, leading as will be discussed to impaired cardiac energetic status and to further impairment of cardiac function. These metabolic disturbances form a potential target for therapy.
Original languageEnglish
Pages (from-to)595-606
Number of pages12
JournalHeart Failure Reviews
Issue number5
Early online date4 Nov 2012
Publication statusPublished - Sept 2013


  • cardiac energetics
  • substrate use
  • metabolic modulation


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