Cardiometabolic health in relation to lifestyle and body weight changes 3–8 years earlier

Tessa M. Van Elten* (Corresponding Author), Mireille N.M. Van Poppel, Reinoud J.B.J. Gemke, Henk Groen, Annemieke Hoek, Ben W. Mol, Tessa J. Roseboom

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
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The degree to which individuals change their lifestyle in response to interventions differs and this variation could affect cardiometabolic health. We examined if changes in dietary intake, physical activity and weight of obese infertile women during the first six months of the LIFEstyle trial were associated with cardiometabolic health 3–8 years later (N = 50–78). Lifestyle was assessed using questionnaires and weight was measured at baseline, 3 and 6 months after randomization. BMI, blood pressure, body composition, pulse wave velocity, glycemic parameters and lipid profile were assessed 3–8 years after randomization. Decreases in savory and sweet snack intake were associated with lower HOMA-IR 3–8 years later, but these associations disappeared after adjustment for current lifestyle. No other associations between changes in lifestyle or body weight during the first six months after randomization with cardiovascular health 3–8 years later were observed. In conclusion, reductions in snack intake were associated with reduced insulin resistance 3–8 years later, but adjustment for current lifestyle reduced these associations. This indicates that changing lifestyle is an important first step, but maintaining this change is needed for improving cardiometabolic health in the long-term.

Original languageEnglish
Article number1953
Number of pages14
Issue number12
Early online date10 Dec 2018
Publication statusPublished - 10 Dec 2018

Bibliographical note

The LIFEstyle study was funded by ZonMw, the Dutch Organization for Health Research and Development, grant number: 50-50110-96-518. The follow-up of the LIFEstyle trial was funded by grants from the Dutch Heart Foundation (2013T085) and the European Commission (Horizon2020 project 633595 DynaHealth). BWM is supported by a NHMRC Practitioner Fellowship (GNT1082548). None of these organizations had a role in data collection, analysis, interpretation of data or writing the report.

Data Availability Statement

Supplementary Materials: The following are available online at, Table S1. Characteristics and baseline cardiometabolic health of participants versus the non-participants.


  • Body weight
  • Cardiometabolic health
  • Dietary intake
  • Lifestyle change
  • Long-term follow-up
  • Physical activity


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