Cell Therapy for Type 1 Diabetes

K. R. Muir, M. J. Lima, H. M. Docherty, K. Docherty

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)
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Cell therapy in the form of human islet transplantation has been a successful form of treatment for patients with type 1 diabetes for over 10 years, but is significantly limited by lack of suitable donor material. A replenishable supply of insulin-producing cells has the potential to address this problem; however to date success has been limited to a few preclinical studies. Two of the most promising strategies include differentiation of embryonic stem cells and induced pluripotent stem cells towards insulin-producing cells and transdifferentiation of acinar or other closely related cell types towards β-cells. Here, we discuss recent progress and challenges that need to be overcome in taking cell therapy to the clinic.
Original languageEnglish
Pages (from-to)253-259
Number of pages7
Issue number4
Early online date29 Jan 2014
Publication statusPublished - Apr 2014

Bibliographical note

The work described in this review was supported by a grant from the MRC. K.R.M. is supported by a fellowship from the Scottish Translational Medicines and Therapeutics Initiative through the Wellcome Trust.


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