Challenges in measuring and understanding biological noise

Nils Eling, Michael D. Morgan, John C. Marioni

Research output: Contribution to journalArticlepeer-review

Abstract

Biochemical reactions are intrinsically stochastic, leading to variation in the production of mRNAs and proteins within cells. In the scientific literature, this source of variation is typically referred to as ‘noise’. The observed variability in molecular phenotypes arises from a combination of processes that amplify and attenuate noise. Our ability to quantify cell-to-cell variability in numerous biological contexts has been revolutionized by recent advances in single-cell technology, from imaging approaches through to ‘omics’ strategies. However, defining, accurately measuring and disentangling the stochastic and deterministic components of cell-to-cell variability is challenging. In this Review, we discuss the sources, impact and function of molecular phenotypic variability and highlight future directions to understand its role.
Original languageEnglish
Article number20
Pages (from-to)536-548
Number of pages14
JournalNature Reviews Genetics
DOIs
Publication statusPublished - 21 May 2019

Bibliographical note

Author Correction: Challenges in measuring and understanding biological noise https://doi.org/10.1038/s41576-019-0142-2

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