Challenges in the management of pleomorphic lobular carcinoma in situ of the breast

Yazan A Masannat, Salena K Bains, Sarah E Pinder, Arnie D Purushotham

Research output: Contribution to journalReview articlepeer-review

30 Citations (Scopus)


BACKGROUND: Pleomorphic Lobular Carcinoma in Situ (PLCIS) is a pathological variant of Lobular Carcinoma in Situ (LCIS) with distinct features. Since first described over a decade ago there are only few papers published about this condition.

METHODS: Medline and Pubmed based literature overview was done with the aim of describing the different histopathological, radiological and clinical features of this pathological entity to highlight the different clinicopathological presentations and modalities of treatment described.

RESULTS: PLCIS has different biological features when compared to LCIS. It is more likely to be associated with invasive disease and the immuno-histochemical profile shows it is less likely to be ER and PR positive with higher positivity of HER2, Ki-67and p53. It has been suggested that PLCIS should be treated more aggressively than LCIS and surgically excised in similar fashion to DCIS.

CONCLUSION: PLCIS is a more aggressive variant of LCIS that needs to be managed differently. Surgical excision with clear margins is advised. Further adjuvant treatments have been described in the literature with little evidence to support their use.

Original languageEnglish
Pages (from-to)194-196
Number of pages3
Issue number2
Early online date26 Jan 2013
Publication statusPublished - Apr 2013

Bibliographical note

Copyright © 2013 Elsevier Ltd. All rights reserved.


  • Breast Neoplasms/diagnostic imaging
  • Carcinoma in Situ/diagnostic imaging
  • Carcinoma, Lobular/diagnostic imaging
  • Female
  • Humans
  • Immunohistochemistry
  • Mammography


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