Characterization of the Myocardial Inflammatory Response in Acute Stress-Induced (Takotsubo) Cardiomyopathy

Heather M. Wilson* (Corresponding Author), Lesley Cheyne, Paul A J Brown, Keith Kerr, Andrew Hannah, Janaki Srinivasan, Natallia Duniak, Graham Horgan, Dana K Dawson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

69 Citations (Scopus)
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Takotsubo cardiomyopathy is an acute stress-induced heart failure syndrome for which the exact pathogenic mechanisms are unclear, and consequently, no specific treatment exists. In an experimental model of stress-induced takotsubo-like cardiomyopathy, the authors describe the temporal course of a chronic inflammatory response post-induction, with an initial early influx of neutrophils into myocardial tissue followed by macrophages that are typical of a proinflammatory M1 phenotype, and a nonsignificant increase in systemic inflammatory cytokines. Post-mortem myocardium from the more complex clinical takotsubo patients share features of the study’s experimental model. These findings suggest modulators of inflammation could be a potential therapeutic option.

Original languageEnglish
Pages (from-to)766-778
Number of pages13
JournalJACC: Basic to Translational Science
Issue number6
Early online date31 Dec 2018
Publication statusPublished - 31 Dec 2018

Bibliographical note

This work was supported by grants from NHS Grampian Endowments and British Heart Foundation Project Grant no. PG/15/108/31928 The authors have reported that they have no relationships relevant to the contents of this paper to disclose.


  • histopathology
  • inflammation
  • macrophage
  • pathophysiology
  • takotsubo cardiomyopathy


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