Chronic pain and premature mortality in men and women, using data from UK Biobank

Research output: Contribution to journalLetter

3 Downloads (Pure)


Muralidharan et al. (1) demonstrated that 4 months after nerve injury, male (but not female) mice demonstrated telomere length reduction and p53-mediated cellular senescence in the spinal cord, which was associated with pain chronicity and a decreased lifespan. They analyzed data from UK Biobank and concluded that their sex-specific observations in mice of a decreased lifespan were replicated in humans. The basis of this conclusion was a finding that among men in UK Biobank, a larger number of pain sites reported at recruitment associated with an earlier age at death (slope –0.19, P = 0.00011), while among women, the relationship between pain sites and death was much weaker and not statistically significant (slope –0.039, P = 0.51). We believe that the method of analysis was inappropriate, and the authors have come to an incorrect conclusion on this specific point.
Original languageEnglish
Article numbere166949
Number of pages3
JournalThe Journal of Clinical Investigation
Issue number5
Publication statusPublished - 1 Mar 2023


Dive into the research topics of 'Chronic pain and premature mortality in men and women, using data from UK Biobank'. Together they form a unique fingerprint.

Cite this