Classification of cardiovascular time series based on different coupling structures using recurrence networks analysis

Gonzalo Marcelo Ramirez Avila, Andrej Gapelyuk, Norbert Marwan, Thomas Walther, Holger Stepan, Juergen Kurths, Niels Wessel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


We analyse cardiovascular time series with the aim of performing early prediction of preeclampsia (PE), a pregnancy-specific disorder causing maternal and foetal morbidity and mortality. The analysis is made using a novel approach, namely the epsilon-recurrence networks applied to a phase space constructed by means of the time series of the variabilities of the heart rate and the blood pressure (systolic and diastolic). All the possible coupling structures among these variables are considered for the analysis. Network measures such as average path length, mean coreness, global clustering coefficient and scale-local transitivity dimension are computed and constitute the parameters for the subsequent quadratic discriminant analysis. This allows us to predict PE with a sensitivity of 91.7 per cent and a specificity of 68.1 per cent, thus validating the use of this method for classifying healthy and preeclamptic patients.

Original languageEnglish
Article number20110623
Number of pages15
JournalPhilosophical Transactions of the Royal Society A: Mathematical, Physical & Engineering Sciences
Issue number1997
Early online date15 Jul 2013
Publication statusPublished - 28 Aug 2013


  • time-series analysis
  • cardiac dynamics
  • networks and genealogical trees
  • hemodynamics
  • blood flow in cardiovascular system
  • coupling analysis
  • heart-rate-variability
  • predicting preeclampsia
  • complex networks
  • uterine perfusion
  • early-pregnancy
  • blood-pressure
  • systems
  • oscillations
  • threshold
  • causality


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