Abstract
In mammals, the pro-inflammatory cytokine interleukin-1 signals through a receptor complex containing a type I interleukin-1 receptor (IL-1RI) and a receptor associated protein (IL-1RAcP). Previously, we have described a cDNA from Atlantic salmon encoding a molecule with homology to the mammalian IL-RI. This molecule was named IL-1 receptor like protein (IL-1RLP) in the absence of functional data to support its proposed role as the salmon IL-1RI. Here, we describe the cloning and characterisation. of a cDNA encoding salmon IL-1RAcP. Like other members of the IL-1R family, the salmon IL-1RAcP encodes three extracellular immunoglobulin-like domains and a cytoplasmic Toll/Interleukin-1 receptor (TIR) domain involved in signalling. Specific binding of salmon IL-1RAcP to IL-1RLP was shown by co-immunoprecipitation studies. (c) 2005 Elsevier Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 53-65 |
Number of pages | 13 |
Journal | Fish & Shellfish Immunology |
Volume | 19 |
DOIs | |
Publication status | Published - 2005 |
Keywords
- Salmo salar
- IL-1R family
- TIR family
- IL-1
- IL-1RLP
- IL-1RAcP
- TROUT ONCORHYNCHUS-MYKISS
- INTERLEUKIN-1 RECEPTOR
- ACCESSORY PROTEIN
- IRAK
- COMPLEX
- FAMILY
- IDENTIFICATION
- EXPRESSION
- PATHWAY
- MEMBER