Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"

Colin Selman, Steven Lingard, David Gems, Linda Partridge, Dominic J Withers

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate-2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.
Original languageEnglish
Pages (from-to)1012
Number of pages1
Issue number5879
Publication statusPublished - 23 May 2008


  • animals
  • brain
  • crosses, genetic
  • diet
  • female
  • homeostasis
  • insulin receptor substrate proteins
  • intracellular signaling peptides and proteins
  • Kaplan-Meiers estimate
  • longevity
  • male
  • mice
  • mice, inbred C57BL
  • mutation
  • phosphoproteins
  • research design
  • signal transduction


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