Common predisposition alleles for moderately common cancers: Bladder cancer

Anne E. Kiltie*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)


Bladder cancer is the 5th commonest cancer and two major risk factors are smoking and occupational chemical exposure. There is also evidence of a genetic component to its aetiology. Candidate gene studies have mostly focused on genes involved in adduct metabolism and DNA repair, including a recent consortium-based meta-analysis. Recently, two genome-wide association studies in bladder cancer have been published and a third is awaited with interest. These first two studies have identified three SNPs of genome-wide significance, two located within the 8q24 'gene desert'. These SNPs are positioned near or within loci of genes potentially implicated in cancer predisposition, namely MYC, TP63 and PSCA, although the functional significance of this is as yet unclear.

Original languageEnglish
Pages (from-to)218-224
Number of pages7
JournalCurrent Opinion in Genetics and Development
Issue number3
Publication statusPublished - Jun 2010

Bibliographical note

Funding Information:
This work was funded by Cancer Research UK (Grant number: C15140/A11505 ).


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