Communication Through Coherence by Means of Cross-frequency Coupling

Joaquín González; Matias Cavelli; Alejandra Mondino; Nicolás Rubido; Adriano Bl Tort; Pablo Torterolo

doi:10.1016/j.neuroscience.2020.09.019

Communication Through Coherence by Means of Cross-frequency Coupling

Joaquín González, Matias Cavelli, Alejandra Mondino, Nicolás Rubido, Adriano Bl Tort^* (Corresponding Author), Pablo Torterolo^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The theory of communication through coherence (CTC) posits the synchronization of brain oscillations as a key mechanism for information sharing and perceptual binding. In a parallel literature, hippocampal theta activity (4-10 Hz) has been shown to modulate the appearance of neocortical fast gamma oscillations (100-150 Hz), a phenomenon known as cross-frequency coupling (CFC). Even though CFC has also been previously associated with information routing, it remains to be determined whether it directly relates to CTC. In particular, for the theta-fast gamma example at hand, a critical question is to know if the phase of the theta cycle influences gamma synchronization across the neocortex. To answer this question, we combined CFC (modulation index) and CTC (phase-locking value) metrics in order to detect the modulation of the cross-regional high-frequency synchronization by the phase of slower oscillations. Upon applying this method, we found that the inter-hemispheric synchronization of neocortical fast gamma during REM sleep depends on the instantaneous phase of the theta rhythm. These results show that CFC is likely to aid long-range information transfer by facilitating the synchronization of faster rhythms, thus consistent with classical CTC views.

Original language	English
Pages (from-to)	157-164
Number of pages	8
Journal	Neuroscience
Volume	449
Early online date	12 Sept 2020
DOIs	https://doi.org/10.1016/j.neuroscience.2020.09.019
Publication status	Published - 21 Nov 2020

Bibliographical note

ACKNOWLEDGMENTS
This study was supported by the Programa de Desarrollode Ciencias Ba ́sicas, PEDECIBA; Agencia Nacional de Investigacio ́neInnovacio ́n(ANII),(FCE_1_2017_1_136550) and the Comisio ́n Sectorialde Investigacio ́n Cientı ́fica (CSIC) I+D-2016-589 grant from Uruguay. J.G was supported by CAP (Comisio ́nAcade ́mica de Posgrado). N.R. acknowledges the CSIC group grant CSIC2018 - FID 13 - Grupo ID 722. A.B.L.T. was supported by Conselho Nacional de Desenvolvimento Cientı ́fico e Tecnolo ́gico (CNPq) and Coordenac ̧a ̃o de Aperfeic ̧oamento de Pessoal de Nı ́velSuperior (CAPES), Brazil.

AUTHOR CONTRIBUTIONS
J.G., M.C and P.T. designed the experiments; J.G., M.C.and A.M conducted the experiments; J.G. and A.B.L.T.wrote analysis software; J.G. analyzed the data; J.G.,M.C., N.R., A.B.L.T. and P.T. were involved in the discussion and interpretation of the results; J.G, A.B.L.T. and P.T. wrote the manuscript.

Keywords

in vivoelectrophysiology
systems neuroscience
synchrony
neuronal oscillations
phase-amplitude coupling
REM sleep
THETA RHYTHM
EEG
HIPPOCAMPUS
in vivo electrophysiology
SYNCHRONIZATION
MEMORY
DYNAMICS
OSCILLATIONS
REM-SLEEP

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Cite this

@article{08296241ea554a47bf563e7e56efa424,

title = "Communication Through Coherence by Means of Cross-frequency Coupling",

abstract = "The theory of communication through coherence (CTC) posits the synchronization of brain oscillations as a key mechanism for information sharing and perceptual binding. In a parallel literature, hippocampal theta activity (4-10 Hz) has been shown to modulate the appearance of neocortical fast gamma oscillations (100-150 Hz), a phenomenon known as cross-frequency coupling (CFC). Even though CFC has also been previously associated with information routing, it remains to be determined whether it directly relates to CTC. In particular, for the theta-fast gamma example at hand, a critical question is to know if the phase of the theta cycle influences gamma synchronization across the neocortex. To answer this question, we combined CFC (modulation index) and CTC (phase-locking value) metrics in order to detect the modulation of the cross-regional high-frequency synchronization by the phase of slower oscillations. Upon applying this method, we found that the inter-hemispheric synchronization of neocortical fast gamma during REM sleep depends on the instantaneous phase of the theta rhythm. These results show that CFC is likely to aid long-range information transfer by facilitating the synchronization of faster rhythms, thus consistent with classical CTC views.",

keywords = "in vivoelectrophysiology, systems neuroscience, synchrony, neuronal oscillations, phase-amplitude coupling, REM sleep, THETA RHYTHM, EEG, HIPPOCAMPUS, in vivo electrophysiology, SYNCHRONIZATION, MEMORY, DYNAMICS, OSCILLATIONS, REM-SLEEP",

author = "Joaqu{\'i}n Gonz{\'a}lez and Matias Cavelli and Alejandra Mondino and Nicol{\'a}s Rubido and {Bl Tort}, Adriano and Pablo Torterolo",

note = "ACKNOWLEDGMENTS This study was supported by the Programa de Desarrollode Ciencias Ba{\' }sicas, PEDECIBA; Agencia Nacional de Investigacio{\' }neInnovacio{\' }n(ANII),(FCE_1_2017_1_136550) and the Comisio{\' }n Sectorialde Investigacio{\' }n Cientı{\' }fica (CSIC) I+D-2016-589 grant from Uruguay. J.G was supported by CAP (Comisio{\' }nAcade{\' }mica de Posgrado). N.R. acknowledges the CSIC group grant CSIC2018 - FID 13 - Grupo ID 722. A.B.L.T. was supported by Conselho Nacional de Desenvolvimento Cientı{\' }fico e Tecnolo{\' }gico (CNPq) and Coordenac{\c }a{\~ }o de Aperfeic{\c }oamento de Pessoal de Nı{\' }velSuperior (CAPES), Brazil. AUTHOR CONTRIBUTIONS J.G., M.C and P.T. designed the experiments; J.G., M.C.and A.M conducted the experiments; J.G. and A.B.L.T.wrote analysis software; J.G. analyzed the data; J.G.,M.C., N.R., A.B.L.T. and P.T. were involved in the discussion and interpretation of the results; J.G, A.B.L.T. and P.T. wrote the manuscript.",

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T1 - Communication Through Coherence by Means of Cross-frequency Coupling

AU - González, Joaquín

AU - Cavelli, Matias

AU - Mondino, Alejandra

AU - Rubido, Nicolás

AU - Bl Tort, Adriano

AU - Torterolo, Pablo

N1 - ACKNOWLEDGMENTS This study was supported by the Programa de Desarrollode Ciencias Ba ́sicas, PEDECIBA; Agencia Nacional de Investigacio ́neInnovacio ́n(ANII),(FCE_1_2017_1_136550) and the Comisio ́n Sectorialde Investigacio ́n Cientı ́fica (CSIC) I+D-2016-589 grant from Uruguay. J.G was supported by CAP (Comisio ́nAcade ́mica de Posgrado). N.R. acknowledges the CSIC group grant CSIC2018 - FID 13 - Grupo ID 722. A.B.L.T. was supported by Conselho Nacional de Desenvolvimento Cientı ́fico e Tecnolo ́gico (CNPq) and Coordenac ̧a ̃o de Aperfeic ̧oamento de Pessoal de Nı ́velSuperior (CAPES), Brazil. AUTHOR CONTRIBUTIONS J.G., M.C and P.T. designed the experiments; J.G., M.C.and A.M conducted the experiments; J.G. and A.B.L.T.wrote analysis software; J.G. analyzed the data; J.G.,M.C., N.R., A.B.L.T. and P.T. were involved in the discussion and interpretation of the results; J.G, A.B.L.T. and P.T. wrote the manuscript.

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Y1 - 2020/11/21

N2 - The theory of communication through coherence (CTC) posits the synchronization of brain oscillations as a key mechanism for information sharing and perceptual binding. In a parallel literature, hippocampal theta activity (4-10 Hz) has been shown to modulate the appearance of neocortical fast gamma oscillations (100-150 Hz), a phenomenon known as cross-frequency coupling (CFC). Even though CFC has also been previously associated with information routing, it remains to be determined whether it directly relates to CTC. In particular, for the theta-fast gamma example at hand, a critical question is to know if the phase of the theta cycle influences gamma synchronization across the neocortex. To answer this question, we combined CFC (modulation index) and CTC (phase-locking value) metrics in order to detect the modulation of the cross-regional high-frequency synchronization by the phase of slower oscillations. Upon applying this method, we found that the inter-hemispheric synchronization of neocortical fast gamma during REM sleep depends on the instantaneous phase of the theta rhythm. These results show that CFC is likely to aid long-range information transfer by facilitating the synchronization of faster rhythms, thus consistent with classical CTC views.

AB - The theory of communication through coherence (CTC) posits the synchronization of brain oscillations as a key mechanism for information sharing and perceptual binding. In a parallel literature, hippocampal theta activity (4-10 Hz) has been shown to modulate the appearance of neocortical fast gamma oscillations (100-150 Hz), a phenomenon known as cross-frequency coupling (CFC). Even though CFC has also been previously associated with information routing, it remains to be determined whether it directly relates to CTC. In particular, for the theta-fast gamma example at hand, a critical question is to know if the phase of the theta cycle influences gamma synchronization across the neocortex. To answer this question, we combined CFC (modulation index) and CTC (phase-locking value) metrics in order to detect the modulation of the cross-regional high-frequency synchronization by the phase of slower oscillations. Upon applying this method, we found that the inter-hemispheric synchronization of neocortical fast gamma during REM sleep depends on the instantaneous phase of the theta rhythm. These results show that CFC is likely to aid long-range information transfer by facilitating the synchronization of faster rhythms, thus consistent with classical CTC views.

KW - in vivoelectrophysiology

KW - systems neuroscience

KW - synchrony

KW - neuronal oscillations

KW - phase-amplitude coupling

KW - REM sleep

KW - THETA RHYTHM

KW - EEG

KW - HIPPOCAMPUS

KW - in vivo electrophysiology

KW - SYNCHRONIZATION

KW - MEMORY

KW - DYNAMICS

KW - OSCILLATIONS

KW - REM-SLEEP

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U2 - 10.1016/j.neuroscience.2020.09.019

DO - 10.1016/j.neuroscience.2020.09.019

M3 - Article

C2 - 32926953

SN - 0306-4522

VL - 449

SP - 157

EP - 164

JO - Neuroscience

JF - Neuroscience

ER -

Communication Through Coherence by Means of Cross-frequency Coupling

Abstract

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Keywords

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Communication Through Coherence by Means of Cross-frequency Coupling

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