Comparative effectiveness of beta-interferons and glatiramer acetate for relapsing-remitting multiple sclerosis: systematic review and network meta-analysis of trials including recommended dosages

G. J. Melendez-Torres; Xavier Armoiry; Rachel Court; Jacoby Patterson; Alan Kan; Peter Auguste; Jason Madan; Carl Counsell; Olga Ciccarelli; Aileen Clarke

doi:10.1186/s12883-018-1162-9

Comparative effectiveness of beta-interferons and glatiramer acetate for relapsing-remitting multiple sclerosis: systematic review and network meta-analysis of trials including recommended dosages

G. J. Melendez-Torres (Corresponding Author), Xavier Armoiry, Rachel Court, Jacoby Patterson, Alan Kan, Peter Auguste, Jason Madan, Carl Counsell, Olga Ciccarelli, Aileen Clarke

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

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Abstract

We systematically reviewed the comparative effectiveness of injectable beta-interferons (IFN-β) and glatiramer acetate (GA) on annualised relapse rate (ARR), progression and discontinuation due to adverse events (AEs) in RRMS, using evidence from within the drugs’ recommended dosages.

Original language	English
Article number	162
Journal	BMC Neurology
Volume	18
DOIs	https://doi.org/10.1186/s12883-018-1162-9
Publication status	Published - 3 Oct 2018

Bibliographical note

This work is part of a larger report commissioned by the NIHR HTA Programme as project number ID809. Aileen Clarke and G.J. Melendez-Torres are partly supported by the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care West Midlands at the University Hospitals Birmingham NHS Foundation Trust. The views expressed are those of the authors and not necessarily those of the NHS, NIHR, NICE or the Department of Health and Social Care.

Keywords

multiple sclerosis
clinically isolated syndrome
beta-interferon
glatiramer acetate
systematic review
economic evaluation

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10.1186/s12883-018-1162-9Licence: CC BY

Comparative effectiveness of beta-interferons and glatiramer acetate for relapsing-remitting multiple sclerosis
© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Final published version, 844 KBLicence: CC BY

Cite this

Melendez-Torres, G. J., Armoiry, X., Court, R., Patterson, J., Kan, A., Auguste, P., Madan, J., Counsell, C., Ciccarelli, O., & Clarke, A. (2018). Comparative effectiveness of beta-interferons and glatiramer acetate for relapsing-remitting multiple sclerosis: systematic review and network meta-analysis of trials including recommended dosages. BMC Neurology, 18, Article 162. https://doi.org/10.1186/s12883-018-1162-9

Comparative effectiveness of beta-interferons and glatiramer acetate for relapsing-remitting multiple sclerosis: systematic review and network meta-analysis of trials including recommended dosages. / Melendez-Torres, G. J. (Corresponding Author); Armoiry, Xavier; Court, Rachel et al.
In: BMC Neurology, Vol. 18, 162, 03.10.2018.

Research output: Contribution to journal › Article › peer-review

Melendez-Torres, GJ, Armoiry, X, Court, R, Patterson, J, Kan, A, Auguste, P, Madan, J, Counsell, C, Ciccarelli, O & Clarke, A 2018, 'Comparative effectiveness of beta-interferons and glatiramer acetate for relapsing-remitting multiple sclerosis: systematic review and network meta-analysis of trials including recommended dosages', BMC Neurology, vol. 18, 162. https://doi.org/10.1186/s12883-018-1162-9

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Comparative effectiveness of beta-interferons and glatiramer acetate for relapsing-remitting multiple sclerosis: systematic review and network meta-analysis of trials including recommended dosages

Abstract

Bibliographical note

Keywords

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