Abstract
Objects: Joint morphology is a risk factor for hip osteoarthritis (HOA) and could
explain ethnic differences in HOA prevalence. Therefore, we aimed to compare the prevalence of radiographic HOA (rHOA) and hip morphology between the
predominantly White UK Biobank (UKB) and exclusively Chinese Shanghai Changfeng (SC) cohorts.
Methods: Left hip iDXA scans were used to quantify rHOA, from a combination of
osteophytes (grade>1) and joint space narrowing (grade>1), and hip morphology. Using an 85-point Statistical Shape Model (SSM) we evaluated cam (alpha angle (AA)≥60°) and pincer (lateral centre edge angle (LCEA) ≥45°) morphology and acetabular dysplasia (LCEA <25°). Diameter of the femoral head (DFH), femoral neck width (FNW) and hip axis length (HAL) were also obtained from these points. Results were adjusted for differences in age, height and weight and stratified by sex.
Results: Complete data were available for 5,924 SC and 39,020 White UKB
participants with mean ages of 63.4 and 63.7 years old. rHOA prevalence was
considerably lower in female (2.2% versus 13.1%) and male (12.0% and 25.1%) SC
49 compared to UKB participants. Cam morphology, rarely seen in females, was less common in SC compared with UKB males (6.3% versus 16.5%). Composite SSM modes, scaled to the same overall size, revealed SC participants to have a wider femoral head compared to UKB participants. FNW and HAL were smaller in SC compared to UKB, whereas DFH/FNW ratio was higher in SC.
Conclusions: rHOA prevalence is lower in Chinese compared with White individuals. Several differences in hip shape were observed, including frequency of cam morphology, FNW and DFH/FNW ratio. These characteristics have previously been identified as risk factors for HOA and may contribute to observed ethnic differences in HOA prevalence.
explain ethnic differences in HOA prevalence. Therefore, we aimed to compare the prevalence of radiographic HOA (rHOA) and hip morphology between the
predominantly White UK Biobank (UKB) and exclusively Chinese Shanghai Changfeng (SC) cohorts.
Methods: Left hip iDXA scans were used to quantify rHOA, from a combination of
osteophytes (grade>1) and joint space narrowing (grade>1), and hip morphology. Using an 85-point Statistical Shape Model (SSM) we evaluated cam (alpha angle (AA)≥60°) and pincer (lateral centre edge angle (LCEA) ≥45°) morphology and acetabular dysplasia (LCEA <25°). Diameter of the femoral head (DFH), femoral neck width (FNW) and hip axis length (HAL) were also obtained from these points. Results were adjusted for differences in age, height and weight and stratified by sex.
Results: Complete data were available for 5,924 SC and 39,020 White UKB
participants with mean ages of 63.4 and 63.7 years old. rHOA prevalence was
considerably lower in female (2.2% versus 13.1%) and male (12.0% and 25.1%) SC
49 compared to UKB participants. Cam morphology, rarely seen in females, was less common in SC compared with UKB males (6.3% versus 16.5%). Composite SSM modes, scaled to the same overall size, revealed SC participants to have a wider femoral head compared to UKB participants. FNW and HAL were smaller in SC compared to UKB, whereas DFH/FNW ratio was higher in SC.
Conclusions: rHOA prevalence is lower in Chinese compared with White individuals. Several differences in hip shape were observed, including frequency of cam morphology, FNW and DFH/FNW ratio. These characteristics have previously been identified as risk factors for HOA and may contribute to observed ethnic differences in HOA prevalence.
| Original language | English |
|---|---|
| Journal | Osteoarthritis and Cartilage |
| Early online date | 5 Nov 2023 |
| DOIs | |
| Publication status | E-pub ahead of print - 5 Nov 2023 |
Bibliographical note
AcknowledgementsWe express our deep appreciation to the members of the Department of
Endocrinology and Metabolism, Zhongshan Hospital for their assistance for collecting data of the SC cohort. This work was also conducted using the UK Biobank resource, access application 17295.
Data Availability Statement
Data availability statementThe UK Biobank Study rHOA data from this study will be available in a forthcoming
data release as it has been returned to the UK Biobank Study. Users must be registered with UK Biobank to access their resources (https://bbams.ndph.ox.ac.uk/ams/)