CONQUEST: a quality improvement program for defining and optimizing standards of care for modifiable high-risk COPD patients

Luis Alves, Rachel Pullen, John R. Hurst, Marc Miravitlles, Victoria Carter, Rongchang Chen, Amy Couper, Mark Dransfield, Alexander Evans, Antony Hardjojo, David Jones, Rupert Jones, Margee Kerr, Konstantinos Kostikas, Jonathan Marshall, Fernando J Martinez , Marije van Melle, Marije van Melle, Ruth B Murray, Shigeo MuroClementine Nordon, Michael Pollack, Chris Price, Anita Sharma, Dave Singh, Tonya A Winders, David Price* (Corresponding Author)

*Corresponding author for this work

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The COllaboratioN on QUality improvement initiative for achieving Excellence in STandards of COPD care (CONQUEST) aims to improve the quality of COPD care in primary care. The CONQUEST target population includes patients diagnosed with COPD, and those undiagnosed but with COPD-like exacerbations, who are at high but modifiable risk of COPD exacerbations, increased morbidity, and
mortality. Timely diagnosis and optimized management to reduce these risks is vital. There is a need for a quality improvement program (QIP) that enables long-term improvement of patient clinical outcomes via integration of the program into routine clinical care.
Core to the CONQUEST program is the adoption of four specifically designed, globally applicable, and expert-agreed quality standards(QS) for modifiable high-risk COPD patients. Translation of the QS into clinical practice, and implementation of the QIP, is guided by the CONQUEST global operational
protocol provided to sites meeting the minimum healthcare system requirements. Initial analyses of current practices are conducted to generate baseline assessments of need within healthcare systems and sites looking to implement the QIP. Implementation is supported by the provision of CONQUEST
resources and tools, such as clinical decision support, that promote prompt identification and treatment of patients. Utilization of electronic medical record (EMR) and patient-reported data are integral components of the QIP. Regular, automated collection and analysis of data, combined with a cyclical review of the implementation process, will be conducted for long-term, continuous improvement and health impact evaluation.
The CONQUEST QIP will be an important resource in the identification and management of patients with modifiable high-risk COPD. Embedding the CONQUEST QS into routine clinical practice with regular evaluation and feedback will result in long-term quality of care improvement.
Original languageEnglish
Pages (from-to)53-68
Number of pages16
JournalPatient Related Outcome Measures
Issue number13
Early online date23 Feb 2022
Publication statusPublished - 23 Feb 2022

Bibliographical note

This study was conducted by Optimum Patient Care Global and the Observational and Pragmatic Research Institute (OPRI) Pte Ltd and was co-funded by Optimum Patient Care Global and AstraZeneca. No funding was received by the Observational & Pragmatic Research Institute Pte Ltd (OPRI) for its contribution.

Hana Muellerova, Patrick Darken, Paul Dorinsky, Frank Trudo, and Alex De Giorgio-Miller of AstraZeneca are acknowledged for their contribution to protocol development. Writing, editorial support, and/or formatting assistance in the development of this manuscript was provided by Shilpa Suresh, MSc, of the Observational and Pragmatic Research Institute, Singapore. Professor Dave Singh
is supported by the National Institute for Health Research (NIHR) Manchester Biomedical Research Centre (BRC).


  • Patient-reported outcome
  • Patient-reported information
  • Clinical decision support
  • Primary care
  • Quality standards
  • Integrated care


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