Contact sensitivity to preservatives in the UK, 2004-2005: Results of multicentre study

Cherng T. Jong, Barry N. Statham, Cathy M. Green, Codagh M. King, David J. Gawkrodger, Jane E. Sansom, John S. C. English, S. Mark Wilkinson, Anthony Ormerod, Mahbub M. U. Chowdhury

Research output: Contribution to journalArticlepeer-review

73 Citations (Scopus)


Preservative sensitivity in the UK was last assessed in 2000. Given the changes in preservative usage, we have re-evaluated our patch test data in order to detect any changes in the trend of sensitization. The results of patch testing using the extended British Contact Dermatitis Society Standard series were collected from 9 dermatology centres in the UK. Positive reactions to each of 10 preservative allergens were captured together with the MOAHFLA indices for each centre. In total, 6958 patients were tested during the period 2004-2005. The current data were compared with previously published data. Formaldehyde and methylchloroisothiazolinone/methyl-isothiazolinone have the highest positivity rates at 2.0% and chloroxylenol the lowest at 0.2%. Parabens mix has the highest irritancy rate. Compared with the UK data in 2000, the positivity rate of imidazolidinyl urea (0.02 <P <0.05) has significantly increased and that of methyldibromo glutaronitrile has significantly reduced (P <0.001).
Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalContact Dermatitis
Issue number3
Early online date12 Jul 2007
Publication statusPublished - Sept 2007


  • adult
  • cosmetics
  • dermatitis, allergic contact
  • female
  • food preservatives
  • Great Britain
  • humans
  • male
  • multicenter studies as topic
  • patch tests
  • preservatives, pharmaceutical
  • biocide
  • preservative
  • sensitivity


Dive into the research topics of 'Contact sensitivity to preservatives in the UK, 2004-2005: Results of multicentre study'. Together they form a unique fingerprint.

Cite this