Cost-effectiveness of in vitro fertilization and embryo transfer

Ben W.J. Mol*, Gouke J. Bonsel, John A. Collins, Maarten A.H.M. Wiegerinck, Fulco Van Der Veen, Patrick M.M. Bossuyt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


Objective: Economic analyses in reproductive medicine often fail to take into account the chances of treatment-independent conception. We compared the cost-effectiveness of several realistic strategies involving IVF using no treatment as the reference strategy. Design: A decision tree was constructed for a subfertile couple in which the clinician had to decide whether to offer treatment with IVF. No treatment at all was used as the reference strategy.Setting: An analytic decision-making framework. Patient(s): Hypothetical subfertile couples. Intervention(s): Two potential treatment approaches: three IVF cycles performed as soon as possible, or no treatment performed initially and then three or four IVF cycles performed if a pregnancy resulting in a live birth does not occur naturally after 212 years. Main Outcome Measure(s): The cost of establishing one pregnancy that results in a live birth. Result(s): The cost-effectiveness of IVF depended not only on the costs and expected success rates of IVF itself but also on the couple-specific chances of treatment-independent conception. Consequently, the cost-effectiveness of IVF is strongly dependent on the age of the female partner. This finding corresponds with everyday clinical experience. Conclusion(s): Economic analyses in reproductive medicine should take into account the option of providing no treatment. Copyright (C) 2000 American Society for Reproductive Medicine.

Original languageEnglish
Pages (from-to)748-754
Number of pages7
JournalFertility and Sterility
Issue number4
Publication statusPublished - 1 Apr 2000


  • Cost-effectiveness
  • Economic analysis
  • IVF


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