Crystal structure of azilsartan methyl ester ethyl acetate hemisolvate

Zhengyi Li, Rong Liu, Meilan Zhu, Liang Chen, Xiaoqiang Sun*, W. T A Harrison (Editor)

*Corresponding author for this work

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The title compound, C26H22N4O5 (systematic name: methyl 2-ethoxy-1-{4-[2-(5-oxo-4, 5-dihydro-1, 2, 4-oxadiazol-3-yl)phen-yl]benzyl}-1 H-1, 3-benzodiazole-7-carboxylate ethyl acetate hemisolvate), was obtained via cyclization of methyl (Z)-2-ethoxy-1-{(2′-(N′-hydroxycarbamimidoyl)-[1, 1′-biphenyl]-4-yl)methyl}-1 H-benzo[d]imidazole-7-carboxylate with diphen-yl carbonate. There are two independent molecules (A and B) with different conformations and an ethyl acetate solvent molecule in the asymmetric unit. In molecule A, the dihedral angle between the benzene ring and its attached oxadiazole ring is 59.36 (17); the dihedral angle between the benzene rings is 43.89 (15) and that between the benzene ring and its attached imidazole ring system is 80.06 (11)°. The corresponding dihedral angles in molecule B are 58.45 (18), 50.73 (16) and 85.37 (10)°, respectively. The C - O - C - Cm (m = methyl) torsion angles for the ethoxy side chains attached to the imidazole rings in molecules A and B are 93.9 (3) and - 174.6 (3)°, respectively. In the crystal, the components are linked by N - H⋯N and C - H⋯O hydrogen bonds, generating a three-dimensional network. Aromatic π-π stacking interactions [shortest centroid-centroid separation = 3.536 (3)Å] are also observed.

Original languageEnglish
Pages (from-to)o84-o85
Number of pages2
JournalActa Crystallographica Section E: Structure Reports Online
Issue number2
Early online date3 Jan 2015
Publication statusPublished - 1 Feb 2015

Bibliographical note

We gratefully acknowledge financial support from the NSFC (No. 21002009), the Scientific and Technological Project of Jiangsu Province (BY2014037–01), the Major Program for Natural Science Research of Jiangsu Colleges and Universities (12 K J A150002, 14 K J A150002) and the Qing Lan Project of Jiangsu Province.


  • Antihypertension
  • Azilsartan
  • Azilsartan methyl ester
  • Crystal structure


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