Daily energy expenditure through the human life course

IAEA DLW Database Consortium; Amy H.  Luke; Jennifer Rood; Dale A Schoeller; Klaas R. Westerterp; William W Wong

doi:10.1126/science.abe5017

Daily energy expenditure through the human life course

IAEA DLW Database Consortium, Amy H. Luke^* (Corresponding Author), Jennifer Rood^* (Corresponding Author), Dale A Schoeller^* (Corresponding Author), Klaas R. Westerterp^* (Corresponding Author), William W Wong^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

220 Citations (Scopus)

Abstract

Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

Original language	English
Pages (from-to)	808-812
Number of pages	5
Journal	Science
Volume	373
Issue number	6556
Early online date	13 Aug 2021
DOIs	https://doi.org/10.1126/science.abe5017
Publication status	Published - 13 Aug 2021

Bibliographical note

Funding Information:
The IAEA Doubly Labeled Water (DLW) Database is generously supported by the IAEA, Taiyo Nippon Sanso, and SERCON. The authors also gratefully acknowledge funding from the US National Science Foundation (BCS-1824466) awarded to H.P. The funders played no role in the content of this manuscript.

Data Availability Statement

All data used in these analyses is freely available via the IAEA DLW Database, which can be found at https://doubly-labelled-water-database.iaea.org/home and www.dlwdatabase.org.

SUPPLEMENTARY MATERIALS

science.sciencemag.org/content/373/6556/808/suppl/DC1
Materials and Methods
Figs. S1 to S10
Tables S1 to S4
IAEA DLW Database Consortium Collaborators List
References (30–54)
MDAR Reproducibility Checklist

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1126/science.abe5017Licence: Unspecified

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title = "Daily energy expenditure through the human life course",

abstract = "Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.",

author = "Herman Pontzer and Yosuke Yamada and Hiroyuki Sagayama and Ainslie, {Philip N.} and Andersen, {Lene F.} and Anderson, {Liam J.} and Lenore Arab and Issaad Baddou and Kweku Bedu-Addo and Blaak, {Ellen E.} and Stephane Blanc and Bonomi, {Alberto G.} and Bouten, {Carlijn V.C.} and Pascal Bovet and Buchowski, {Maciej S.} and Butte, {Nancy F.} and Camps, {Stefan G.} and Close, {Graeme L.} and Cooper, {Jamie A.} and Richard Cooper and Das, {Sai Krupa} and Dugas, {Lara R.} and Ulf Ekelund and Sonja Entringer and Terrence Forrester and Fudge, {Barry W.} and Goris, {Annelies H.} and Michael Gurven and Catherine Hambly and {El Hamdouchi}, Asmaa and Hoos, {Marjije B.} and Sumei Hu and Noorjehan Joonas and Joosen, {Annemiek M.} and Peter Katzmarzyk and Kempen, {Kitty P.} and Misaka Kimura and Kraus, {William E.} and Kushner, {Robert F.} and Lambert, {Estelle V.} and Leonard, {William R.} and Nader Lessan and Corby Martin and Medin, {Anine C.} and Meijer, {Erwin P.} and Morehen, {James C.} and Morton, {James P.} and Neuhouser, {Marian L.} and Xueying Zhang and Speakman, {John R.} and {IAEA DLW Database Consortium} and Luke, {Amy H.} and Jennifer Rood and Schoeller, {Dale A} and Westerterp, {Klaas R.} and Wong, {William W}",

note = "Funding Information: The IAEA Doubly Labeled Water (DLW) Database is generously supported by the IAEA, Taiyo Nippon Sanso, and SERCON. The authors also gratefully acknowledge funding from the US National Science Foundation (BCS-1824466) awarded to H.P. The funders played no role in the content of this manuscript. ",

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doi = "10.1126/science.abe5017",

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AU - Pontzer, Herman

AU - Yamada, Yosuke

AU - Sagayama, Hiroyuki

AU - Ainslie, Philip N.

AU - Andersen, Lene F.

AU - Anderson, Liam J.

AU - Arab, Lenore

AU - Baddou, Issaad

AU - Bedu-Addo, Kweku

AU - Blaak, Ellen E.

AU - Blanc, Stephane

AU - Bonomi, Alberto G.

AU - Bouten, Carlijn V.C.

AU - Bovet, Pascal

AU - Buchowski, Maciej S.

AU - Butte, Nancy F.

AU - Camps, Stefan G.

AU - Close, Graeme L.

AU - Cooper, Jamie A.

AU - Cooper, Richard

AU - Das, Sai Krupa

AU - Dugas, Lara R.

AU - Ekelund, Ulf

AU - Entringer, Sonja

AU - Forrester, Terrence

AU - Fudge, Barry W.

AU - Goris, Annelies H.

AU - Gurven, Michael

AU - Hambly, Catherine

AU - El Hamdouchi, Asmaa

AU - Hoos, Marjije B.

AU - Hu, Sumei

AU - Joonas, Noorjehan

AU - Joosen, Annemiek M.

AU - Katzmarzyk, Peter

AU - Kempen, Kitty P.

AU - Kimura, Misaka

AU - Kraus, William E.

AU - Kushner, Robert F.

AU - Lambert, Estelle V.

AU - Leonard, William R.

AU - Lessan, Nader

AU - Martin, Corby

AU - Medin, Anine C.

AU - Meijer, Erwin P.

AU - Morehen, James C.

AU - Morton, James P.

AU - Neuhouser, Marian L.

AU - Zhang, Xueying

AU - Speakman, John R.

AU - IAEA DLW Database Consortium

AU - Luke, Amy H.

AU - Rood, Jennifer

AU - Schoeller, Dale A

AU - Westerterp, Klaas R.

AU - Wong, William W

N1 - Funding Information: The IAEA Doubly Labeled Water (DLW) Database is generously supported by the IAEA, Taiyo Nippon Sanso, and SERCON. The authors also gratefully acknowledge funding from the US National Science Foundation (BCS-1824466) awarded to H.P. The funders played no role in the content of this manuscript.

PY - 2021/8/13

Y1 - 2021/8/13

N2 - Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

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VL - 373

SP - 808

EP - 812

JO - Science

JF - Science

IS - 6556

ER -

Daily energy expenditure through the human life course

Abstract

Bibliographical note

Data Availability Statement

UN SDGs

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