Abstract
The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease.
Original language | English |
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Pages (from-to) | 55-65 |
Number of pages | 11 |
Journal | Mammalian Genome |
Volume | 22 |
Issue number | 1 |
Early online date | 11 Aug 2010 |
DOIs | |
Publication status | Published - Feb 2011 |
Keywords
- animals
- fungi
- humans
- membrane proteins
- mycoses
- nerve tissue proteins
- polymorphism, genetic