TY - GEN
T1 - Deregulation of lipid composition in peri-tumoural adipose tissue in postmenopausal patients with breast cancer
AU - Cheung, Sai Man
AU - Mallikourti, Vasiliki
AU - Gagliardi, Tanja
AU - Husain, Ehab
AU - Masannat, Yazan
AU - Heys, Steven
AU - He, Jiabao
N1 - The authors would like to thank Dr Matthew Clemence for clinical scientist support, Ms Angela Allan and Ms Vera Herd for nurse support, Ms Shona Davidson, Ms Linda Lett, Ms Louisa Pirie, Ms Fiona Geddes, Ms Kate Shaw, Ms Sheila Ingram for patient recruitment support, Ms Kim Blake, Ms Shona Stuart, Ms Brenda Still, Ms Dawn Younie for logistic support, and Ms Beverly MacLennan, Ms Nichola Crouch, Ms Laura Reid and Mr Mike Hendry for radiographer support. The authors would also like to thank Ms Mairi Fuller, Mr Dionysios Koufoudakis, Ms Elizabeth Smyth and Ms Beatrix Elsberger for providing access to the patients. This project was funded by Friends of Aberdeen and North Centre for Haematology, Oncology and Radiotherapy (ANCHOR). Sai Man Cheung’s PhD study was jointly supported by Elphinstone scholarship, Roland Sutton Academic Trust and John Mallard scholarship and is currently funded by Cancer Research UK. Vasiliki Mallikourti’s PhD study is supported by Tenovus Scotland PhD studentship.
PY - 2021/4/30
Y1 - 2021/4/30
N2 - Deregulation of lipid metabolism has been shown in BRCA1/2 genetic mutation carriers. Mammary adipose tissues in postmenopausal women are the primary sites of oestrogen production linked to tumour initiation and progression. Therefore, lipid composition in postmenopausal breast plays a key role in breast cancer monitoring and subsequent development of prevention strategies. Previous studies focused on cell or animal models and invasive lipid extraction methods, while conventional MRS is inadequate in complete lipid composition measurement. We hypothesised that lipid composition in peri-tumoural breast adipose tissue is affected by the presence of tumour in postmenopausal women, using a non-invasive 2D MRS approach.
AB - Deregulation of lipid metabolism has been shown in BRCA1/2 genetic mutation carriers. Mammary adipose tissues in postmenopausal women are the primary sites of oestrogen production linked to tumour initiation and progression. Therefore, lipid composition in postmenopausal breast plays a key role in breast cancer monitoring and subsequent development of prevention strategies. Previous studies focused on cell or animal models and invasive lipid extraction methods, while conventional MRS is inadequate in complete lipid composition measurement. We hypothesised that lipid composition in peri-tumoural breast adipose tissue is affected by the presence of tumour in postmenopausal women, using a non-invasive 2D MRS approach.
UR - https://cds.ismrm.org/protected/21MProceedings/
M3 - Published conference contribution
T3 - Proceedings of the ISMRM & SMRT Annual Meeting & Exhibition
BT - Proceedings of the 2021 ISMRM & SMRT Annual Meeting & Exhibition
PB - ISMRM
T2 - International Society for Magnetic Resonance in Medicine (ISMRM)
Y2 - 15 May 2021 through 20 May 2021
ER -
