Detection of IL-36γ through noninvasive tape stripping reliably discriminates psoriasis from atopic eczema

Anna Berekméri, Anne Latzko, Adewonuola Alase, Tom Macleod, Joseph S Ainscough, Philip Laws, Mark Goodfield, Andrew Wright, Philip Helliwell, Sara Edward, Gordon D Brown, Delyth M Reid, Joerg Wenzel, Martin Stacey, Miriam Wittmann (Corresponding Author)

Research output: Contribution to journalLetterpeer-review

25 Citations (Scopus)
9 Downloads (Pure)

Abstract

This report demonstrates that sampling and detection of IL-36γ protein by non-invasive tape stripping of skin lesion provides a highly sensitive and selective diagnostic for psoriatic inflammation.

Original languageEnglish
Pages (from-to)988-991
Number of pages4
JournalJournal of Allergy and Clinical Immunology
Volume142
Issue number3
Early online date18 May 2018
DOIs
Publication statusPublished - Sept 2018

Bibliographical note

This project was mainly supported by a 2014 Pfizer Inflammation Competitive Research Programme (ICRP). In addition, assay development support was received by MRC grant MR/M01942X/1. GDB and DMR were funded by the Wellcome Trust (102705, 97377), the MRC Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1).

Some of the samples included in the atopic dermatitis comparator group were acquired in the context of the National Institute for Health Research (NIHR) funded ALPHA trial (EUDRACT 2014-004741-27) – explorative biomarker substudy. The ALPHA trial was developed in collaboration with the Clinical Trials Research Unit at the University of Leeds with support from the UK Dermatology Clinical Trials Network (UK DCTN). The UK DCTN is grateful to the British Association of Dermatologists and the University of Nottingham for financial support of the Network.

This research is also supported by the NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.

Keywords

  • Psoriasis
  • Atopic Dermatitis
  • Eczema
  • IL-36
  • Diagnostic
  • biomarker

Fingerprint

Dive into the research topics of 'Detection of IL-36γ through noninvasive tape stripping reliably discriminates psoriasis from atopic eczema'. Together they form a unique fingerprint.

Cite this