Abstract
Objectives
To develop a prognostic model to predict mortality in Parkinson's disease (PD).
Background
Prognostic models can be used for individual prediction, case-mix correction, and clinical trial design. No prognostic model has been published for use in PD.
Methods
The PINE study (198 patients) and ParkWest study (192 patients) are community-based, incidence cohorts of PD with lifelong prospective follow-up in North-East Scotland and Western Norway, respectively. In each study area, all incident cases were identified with community-based ascertainment strategies (2004–6 and 2006–9 in PINE; 2004–7 in ParkWest). Clinical predictors measured at diagnosis in the PINE cohort were combined to create a prognostic model of mortality using Weibull regression. It was externally validated by measuring calibration (observed versus predicted risk in quantiles of risk) and discrimination in the ParkWest cohort.
To develop a prognostic model to predict mortality in Parkinson's disease (PD).
Background
Prognostic models can be used for individual prediction, case-mix correction, and clinical trial design. No prognostic model has been published for use in PD.
Methods
The PINE study (198 patients) and ParkWest study (192 patients) are community-based, incidence cohorts of PD with lifelong prospective follow-up in North-East Scotland and Western Norway, respectively. In each study area, all incident cases were identified with community-based ascertainment strategies (2004–6 and 2006–9 in PINE; 2004–7 in ParkWest). Clinical predictors measured at diagnosis in the PINE cohort were combined to create a prognostic model of mortality using Weibull regression. It was externally validated by measuring calibration (observed versus predicted risk in quantiles of risk) and discrimination in the ParkWest cohort.
| Original language | English |
|---|---|
| Article number | 096 |
| Number of pages | 2 |
| Journal | Journal of Neurology, Neurosurgery & Psychiatry |
| Volume | 87 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2016 |
| Event | Annual Meeting of the Association-of-British-Neurologists (ABN) - 2016 - Brighton Duration: 17 May 2016 → 19 May 2016 |