Development of Nanoparticles for Drug Delivery to Brain Tumor: The Effect of Surface Materials on Penetration Into Brain Tissue

Chenlu Lei; Pooya Davoodi; Wenbo Zhan; Pierce Kah-Hoe Chow; Chi-Hwa Wang

doi:10.1016/j.xphs.2018.12.002

Development of Nanoparticles for Drug Delivery to Brain Tumor: The Effect of Surface Materials on Penetration Into Brain Tissue

Chenlu Lei, Pooya Davoodi, Wenbo Zhan, Pierce Kah-Hoe Chow, Chi-Hwa Wang

Engineering

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Surface-modified poly(d,l-lactic-co-glycolic acid) PLGA nanoparticles (NPs) were fabricated via nanoprecipitation for obtaining therapeutic concentration of paclitaxel (PTX) in brain tumor. The cellular uptake and cytotoxicity of NPs were evaluated on C6 glioma cells in vitro, and BALB/c mice were used to study the brain penetration and biodistribution upon intravenous administration. Results showed that by finely tuning nanoprecipitation parameters, PLGA NPs coated with surfactants with a size around 150 nm could provide a sustained release of PTX for >2 weeks. Surface coatings could increase cellular uptake efficiency when compared with noncoated NPs, and d-α-tocopherol polyethylene glycol 1000 succinate (TPGS) showed the most significant enhancement. The in vivo evaluation of TPGS-PLGA NPs showed amplified accumulation (>800% after 96 h) of PTX in the brain tissue when compared with bare NPs and Taxol®. Therefore, PLGA-NPs with PLGA-TPGS coating demonstrate a promising approach to efficiently transport PTX across blood-brain barrier in a safer manner, with the advantages of easy formulation, lower production cost, and higher encapsulation efficiency.

Original language	English
Pages (from-to)	1736-1745
Number of pages	10
Journal	Journal of Pharmaceutical Sciences
Volume	108
Issue number	5
Early online date	12 Dec 2018
DOIs	https://doi.org/10.1016/j.xphs.2018.12.002
Publication status	Published - May 2019

Keywords

drug delivery
nanoparticles
surface coating
blood-brain barrier
brain tumor
VITAMIN-E-TPGS
PACLITAXEL TAXOL(R)
PLA NANOPARTICLES
BIODEGRADABLE NANOPARTICLES
P-GLYCOPROTEIN
IN-VITRO
PARTICLE-SIZE
ORAL DELIVERY
PLGA NANOPARTICLES
CREMOPHOR EL

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title = "Development of Nanoparticles for Drug Delivery to Brain Tumor: The Effect of Surface Materials on Penetration Into Brain Tissue",

abstract = "Surface-modified poly(d,l-lactic-co-glycolic acid) PLGA nanoparticles (NPs) were fabricated via nanoprecipitation for obtaining therapeutic concentration of paclitaxel (PTX) in brain tumor. The cellular uptake and cytotoxicity of NPs were evaluated on C6 glioma cells in vitro, and BALB/c mice were used to study the brain penetration and biodistribution upon intravenous administration. Results showed that by finely tuning nanoprecipitation parameters, PLGA NPs coated with surfactants with a size around 150 nm could provide a sustained release of PTX for >2 weeks. Surface coatings could increase cellular uptake efficiency when compared with noncoated NPs, and d-α-tocopherol polyethylene glycol 1000 succinate (TPGS) showed the most significant enhancement. The in vivo evaluation of TPGS-PLGA NPs showed amplified accumulation (>800% after 96 h) of PTX in the brain tissue when compared with bare NPs and Taxol{\textregistered}. Therefore, PLGA-NPs with PLGA-TPGS coating demonstrate a promising approach to efficiently transport PTX across blood-brain barrier in a safer manner, with the advantages of easy formulation, lower production cost, and higher encapsulation efficiency. ",

keywords = "drug delivery, nanoparticles, surface coating, blood-brain barrier, brain tumor, VITAMIN-E-TPGS, PACLITAXEL TAXOL(R), PLA NANOPARTICLES, BIODEGRADABLE NANOPARTICLES, P-GLYCOPROTEIN, IN-VITRO, PARTICLE-SIZE, ORAL DELIVERY, PLGA NANOPARTICLES, CREMOPHOR EL",

author = "Chenlu Lei and Pooya Davoodi and Wenbo Zhan and Chow, {Pierce Kah-Hoe} and Chi-Hwa Wang",

year = "2019",

month = may,

doi = "10.1016/j.xphs.2018.12.002",

language = "English",

volume = "108",

pages = "1736--1745",

journal = "Journal of Pharmaceutical Sciences",

issn = "0022-3549",

publisher = "John Wiley and Sons Inc.",

number = "5",

}

TY - JOUR

T1 - Development of Nanoparticles for Drug Delivery to Brain Tumor

T2 - The Effect of Surface Materials on Penetration Into Brain Tissue

AU - Lei, Chenlu

AU - Davoodi, Pooya

AU - Zhan, Wenbo

AU - Chow, Pierce Kah-Hoe

AU - Wang, Chi-Hwa

PY - 2019/5

Y1 - 2019/5

N2 - Surface-modified poly(d,l-lactic-co-glycolic acid) PLGA nanoparticles (NPs) were fabricated via nanoprecipitation for obtaining therapeutic concentration of paclitaxel (PTX) in brain tumor. The cellular uptake and cytotoxicity of NPs were evaluated on C6 glioma cells in vitro, and BALB/c mice were used to study the brain penetration and biodistribution upon intravenous administration. Results showed that by finely tuning nanoprecipitation parameters, PLGA NPs coated with surfactants with a size around 150 nm could provide a sustained release of PTX for >2 weeks. Surface coatings could increase cellular uptake efficiency when compared with noncoated NPs, and d-α-tocopherol polyethylene glycol 1000 succinate (TPGS) showed the most significant enhancement. The in vivo evaluation of TPGS-PLGA NPs showed amplified accumulation (>800% after 96 h) of PTX in the brain tissue when compared with bare NPs and Taxol®. Therefore, PLGA-NPs with PLGA-TPGS coating demonstrate a promising approach to efficiently transport PTX across blood-brain barrier in a safer manner, with the advantages of easy formulation, lower production cost, and higher encapsulation efficiency.

AB - Surface-modified poly(d,l-lactic-co-glycolic acid) PLGA nanoparticles (NPs) were fabricated via nanoprecipitation for obtaining therapeutic concentration of paclitaxel (PTX) in brain tumor. The cellular uptake and cytotoxicity of NPs were evaluated on C6 glioma cells in vitro, and BALB/c mice were used to study the brain penetration and biodistribution upon intravenous administration. Results showed that by finely tuning nanoprecipitation parameters, PLGA NPs coated with surfactants with a size around 150 nm could provide a sustained release of PTX for >2 weeks. Surface coatings could increase cellular uptake efficiency when compared with noncoated NPs, and d-α-tocopherol polyethylene glycol 1000 succinate (TPGS) showed the most significant enhancement. The in vivo evaluation of TPGS-PLGA NPs showed amplified accumulation (>800% after 96 h) of PTX in the brain tissue when compared with bare NPs and Taxol®. Therefore, PLGA-NPs with PLGA-TPGS coating demonstrate a promising approach to efficiently transport PTX across blood-brain barrier in a safer manner, with the advantages of easy formulation, lower production cost, and higher encapsulation efficiency.

KW - drug delivery

KW - nanoparticles

KW - surface coating

KW - blood-brain barrier

KW - brain tumor

KW - VITAMIN-E-TPGS

KW - PACLITAXEL TAXOL(R)

KW - PLA NANOPARTICLES

KW - BIODEGRADABLE NANOPARTICLES

KW - P-GLYCOPROTEIN

KW - IN-VITRO

KW - PARTICLE-SIZE

KW - ORAL DELIVERY

KW - PLGA NANOPARTICLES

KW - CREMOPHOR EL

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UR - http://www.mendeley.com/research/development-nanoparticles-drug-delivery-brain-tumor-effect-surface-materials-penetration-brain-tissu

U2 - 10.1016/j.xphs.2018.12.002

DO - 10.1016/j.xphs.2018.12.002

M3 - Article

SN - 0022-3549

VL - 108

SP - 1736

EP - 1745

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

IS - 5

ER -

Development of Nanoparticles for Drug Delivery to Brain Tumor: The Effect of Surface Materials on Penetration Into Brain Tissue

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Keywords

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