Diarrheal disease and enteric infections in lmic communities: How big is the problem

Benjamin J.J. McCormick, Dennis R. Lang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)


Studies of enteric diseases have historically focused on observations of clinical diarrhea as a cause of mortality and morbidity. Emerging evidence suggests that diarrhea dramatically underestimates both exposure to enteropathogens and the long-term consequences arising from infection. High burden of pathogens in the gut, even in the absence of diarrhea, is common in infants in low and middle income countries. Continual challenge by pathogens, in conjunction with an inadequate diet stimulates an inflammatory disease that alters the structure of the gut, metabolic and immunological pathways and changes the microbiome. Both diarrhea and enteropathogen infection have been associated with reduced growth, reduced cognitive development, and reduced vaccine efficacy suggesting that the burden of diarrheal disease is dramatically underestimated.

Original languageEnglish
Article number11
JournalTropical Diseases, Travel Medicine and Vaccines
Issue number1
Publication statusPublished - 19 Jul 2016

Bibliographical note

Publisher Copyright:
© 2016 The Author(s).


  • Cognitive development
  • Diarrhea
  • Enteric pathogens
  • Enteropathy
  • Growth
  • Malnutrition
  • Sanitation and hygiene
  • Vaccine response


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