Abstract
Cycloaddition of activated furans 10 to 4-methoxycyclopent-2-enone was unexpectedly found to take place with a regioselectivity opposed to that predicted by FMO theory. The reaction represents a direct route towards polyfunctionalised cis-hydrindanones which are key intermediates for the synthesis of ottelione A, a potent inhibitor of tubulin polymerisation. (C) 2000 Elsevier Science Ltd.
Original language | English |
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Pages (from-to) | 6377-6381 |
Journal | Tetrahedron Letters |
Volume | 41 |
Issue number | 33 |
Publication status | Published - 2000 |