Differences in GABAergic transmission between two inputs into the perirhinal cortex

D.L.F. Garden, N. Kemp, Z.I. Bashir

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


We have investigated properties of GABAergic synaptic transmission in perirhinal cortex evoked by stimulation of temporal and entorhinal cortex sides. GABAA IPSCs were isolated by blockade of glutamatergic transmission in slices of adult perirhinal cortex; IPSC decay was best fitted with two exponentials. Interestingly, temporal IPSCs had a larger slow component of decay (P < 0.05) compared to entorhinal IPSCs. Depression of IPSCs by the GABAB receptor agonist baclofen was greater (P < 0.05) in the temporal input (79 ± 4% depression) than the entorhinal input (65 ± 3% depression). Furthermore, baclofen abolished the slow component of IPSC decay in both inputs. Activity-dependent depression of IPSCs at 5 Hz was greater (P < 0.05) in the temporal input [paired pulse ratio (PPR) 0.5 ± 0.04] compared to that in the entorhinal input (PPR 0.67 ± 0.02, n = 10). The differences in paired pulse depression between the inputs were removed by the GABAB receptor antagonist CGP55845A. This study demonstrates several differences in GABA transmission between temporal and entorhinal inputs including the differential activation of presynaptic GABAB receptors and differential regulation of inhibitory synaptic transmission. These properties may be important in the control of neuronal activity within perirhinal cortex.
Original languageEnglish
Pages (from-to)437-444
JournalEuropean Journal of Neuroscience
Issue number3
Publication statusPublished - Aug 2002

Bibliographical note

Supported by University of Bristol and MRC


Dive into the research topics of 'Differences in GABAergic transmission between two inputs into the perirhinal cortex'. Together they form a unique fingerprint.

Cite this