DNA double-strand break formation and repair in Tetrahymena meiosis

Josef Loidl, Alexander Lorenz

Research output: Contribution to journalLiterature reviewpeer-review

18 Citations (Scopus)
14 Downloads (Pure)


The molecular details of meiotic recombination have been determined for a small number of model organisms. From these studies, a general picture has emerged that shows that most, if not all, recombination is initiated by a DNA double-strand break (DSB) that is repaired in a recombinogenic process using a homologous DNA strand as a template. However, the details of recombination vary between organisms, and it is unknown which variant is representative of evolutionarily primordial meiosis or most prevalent among eukaryotes. To answer these questions and to obtain a better understanding of the range of recombination processes among eukaryotes, it is important to study a variety of different organisms. Here, the ciliate Tetrahymena thermophila is introduced as a versatile meiotic model system, which has the additional bonus of having the largest phylogenetic distance to all of the eukaryotes studied to date. Studying this organism can contribute to our understanding of the conservation and diversification of meiotic recombination processes.
Original languageEnglish
Pages (from-to)126-134
Number of pages9
JournalSeminars in Cell & Developmental Biology
Early online date16 Feb 2016
Publication statusPublished - Jun 2016

Bibliographical note

We wish to thank Anura Shodhan for sharing unpublished results and Peter Schlögelhofer and Anura Shodhan for critically reading the manuscript. Part of this work was supported by grant P 27313-B20 from the Austrian Science Fund to JL.


  • meiosis
  • recombination
  • protist
  • DSB
  • crossover


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