The use of preoperative urodynamics as a standard investigation for urinary incontinence (UI) has long been a subject of debate, with a lack of robust evidence to demonstrate improved patients’ outcomes. We aim to compare the clinical and cost effectiveness of urodynamics versus office clinical evaluation only, prior to the treatment of UI. We conducted three linked systematic reviews and meta-analyses of randomised controlled trials (RCTs) comparing urodynamics assessment versus clinical evaluation only in women prior to 1) non-surgical treatment of UI, 2a) surgical treatment of stress urinary incontinence (SUI) and 2b) invasive treatment for overactive bladder (OAB). Women with severe pelvic organ prolapse, previous continence surgery and neuropathic bladder were excluded. Primary outcomes were patient-reported and objective success post-treatment. Secondary outcomes were adverse events, quality of life, sexual function and health economic measures. We searched MEDLINE, Embase and Cochrane Central Register of Controlled Trials databases for each category, which was last updated on January 2019. Study selection, risk of bias assessment and data extraction were performed independently by two reviewers. The random effects model was used to assess risk ratio and mean difference with 95% confidence interval. Statistical heterogeneity was assessed by I2 statistics and the quality of evidence by the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. Four RCTs compared urodynamics versus clinical evaluation only prior to non-surgical management of UI. Treatment consisted of pelvic floor muscle training, with or without pharmacological therapy. Meta-analysis of 150 women showed no evidence of significant difference in the patient-reported and objective success rates between groups (P = 0.520, RR: 0.91, 95% Cl 0.69–1.21, I2 = 0% and P = 0.470, RR:0.87, 95% Cl 0.59–1.28, I2 = n/a, respectively). Seven RCTs were identified for surgical management of SUI. The majority of women underwent mid-urethral tape procedures (retropubic or transobturator approach). Meta-analysis of 1149 women showed no evidence of significant difference in patient-reported (P = 0.850, RR:1.01, 95% CI 0.88–1.16, I2 = 53%) and objective success between groups (P = 0.630, RR:1.02, 95% CI 0.95–1.08, I2 = 28%). There was no significant difference in incidence of voiding dysfunction, de novo urgency, and urinary tract infection between groups. No RCTs were identified for invasive management of OAB. In conclusion, limited evidence shows that routine urodynamics prior to non-surgical management of UI or surgical management of SUI is not associated with improved treatment outcomes, when compared to clinical evaluation only. Well-designed clinical trials are needed to evaluate the clinical and cost-effectiveness of routine urodynamics prior to surgical management of SUI and OAB.
|Number of pages||13|
|Journal||European Journal of Obstetrics and Gynecology and Reproductive Biology|
|Early online date||15 Nov 2019|
|Publication status||Published - Jan 2020|
We would like to thank the University of Aberdeen statisticians for their support throughout and all RCT authors who have addressed our enquiries.
Source of funding
K.Y.L received an Innes Will Endowed Scholarship through the University of Aberdeen Development Trust for medical research. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript for publication.
M.A.F is the chief investigator and A.M. is a co-investigator on the ongoing National Institute for Health Research (NIHR)-funded FUTURE Study evaluating the clinical and cost effectiveness of urodynamics in women with refractory overactive bladder symptoms (https://w3.abdn.ac.uk/hsru/FUTURE/Public/Public/index). They are also part of the team applying for further relevant NIHR funding. Professor Abdel-Fattah and Dr. Mostafa have no potential conflicts of interest for this study. For the full declaration by Professor Abdel-Fattah please see this weblink https://www.abdn.ac.uk/iahs/research/obsgynae/profiles/m.abdelfattah. K.Y.L and M.S. report no conflict of interest.
- Clinical evaluation
- Overactive bladder
- Stress urinary incontinence
- Surgical outcome
- OVERACTIVE BLADDER
- TAPE PROCEDURE
- Urinary Incontinence/therapy
- Urinary Bladder, Overactive/surgery
- Gynecologic Surgical Procedures
- Diagnostic Techniques, Urological
- Preoperative Care