Does the postcoital test predict pregnancy in WHO II anovulatory women? A prospective cohort study

Marleen J. Nahuis*, Nienke S. Weiss, Minke Van Der Velde, Jur J.E. Oosterhuis, Peter G.A. Hompes, Eugenie M. Kaaijk, Job Van Der Palen, Fulco Van Der Veen, Ben Willem J. Mol, Madelon Van Wely

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Objective To assess the capacity of the postcoital test (PCT) to predict pregnancy in WHO II anovulatory women who are ovulatory on clomiphene citrate (CC). In these women, an abnormal PCT result could be associated with lower pregnancy chances, but this has never been proven or refuted. Study design Prospective cohort study was performed between December 2009 and September 2012 for all women who started ovulation induction with CC in one university clinic and two teaching hospitals in the Netherlands. A PCT was performed in one of the first three ovulatory cycles. Ovulation induction with CC was continued for at least six cycles. The PCT was judged to be positive if at least one progressive motile spermatozo was seen in one of five high power fields at 400× magnification. The primary outcome was time to ongoing pregnancy, within six ovulatory cycles. Results In 152 women the PCT was performed. 135 women had a reliable, well-timed PCT. The ongoing pregnancy rate was 44/107 (41%) for a positive and 10/28 (36%) for a negative PCT. The hazard rate for ongoing pregnancy was 1.3 (95% CI 0.64-2.5) for a positive versus a negative PCT. Thirty five of 77 (46%) women with clear mucus had an ongoing pregnancy versus 12 of 45 (27%) women in whom the mucus was not clear (HR 2.0; 95% CI 1.02-3.84, p = 0.04). Conclusion The present study suggests that the outcome of the postcoital test in women with WHO-II anovulation that undergo ovulation induction with CC does not have a large effect on ongoing pregnancy chances over time.

Original languageEnglish
Pages (from-to)127-131
Number of pages5
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Early online date1 Feb 2016
Publication statusPublished - Apr 2016


  • Clomiphene citrate
  • Ovulation induction
  • Polycystic ovary syndrome
  • Postcoital test


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