Domestic airborne fine particulate matter exposure and asthma control among children receiving inhaled steroid treatment

K. E. Woods, A. Apsley, S. Semple, S. W. Turner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The aims of the present study were to measure domestic PM2.5 exposure and explore relationships with indices of asthma severity and control in children prescribed inhaled corticosteroids (ICSs). Disease severity was determined by questionnaire and spirometry. Asthma control was assessed by 5-day peak flow variability (PFV) and children's asthma control test (CACT) on the 1st and 5th day of peak flow testing. Concentrations of PM2.5 were measured over a 24-h period. Twenty-two children were recruited, mean age 11.0 years. Across the 22 homes the median time weighted average (TWA) PM 2.5 concentration (range) was 7.4 μg/m3 (2.0-150.0) and was significantly higher in the seven homes where smoking was reported (24.0 μg/m3) than non-smoking homes (6.0 μg/m3), p=0.001. There was a positive association between TWA PM2.5 and PFV (rho = 0.55, p = 0.015, n = 19) and a negative association between TWA PM2.5 and CACT (rho = - 0.56, p = 0.010, n = 20). TWA PM2.5 exposure was not related to indices of asthma severity. Peak PM2.5 concentration was not associated with any outcome. This exploratory study suggests that even at relatively low concentrations, there is an exposure-response relationship between increasing indoor air PM2.5 concentrations and poorer asthma control in children prescribed ICSs.

Original languageEnglish
Pages (from-to)497-503
Number of pages7
JournalIndoor and Built Environment
Issue number3
Early online date25 Mar 2014
Publication statusPublished - 1 May 2014

Bibliographical note

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.


  • Air pollution indoor
  • Asthma
  • Child
  • Respiratory function testing


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