Dynamic changes of the extracellular matrix after acute tako-tsubo cardiomyopathy

Trevor Ahearn*, Baljit Jagpal, Donnie Cameron, Bernice K. Ng, Caroline Scally, David M. Higgins, John Horowitz, Michael P. Frenneaux, Dana K. Dawson

*Corresponding author for this work

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We have recently demonstrated that cardiac energetic impairment and global myocardial edema persists for at least 4 months after an acute episode of Tako-tsubo cardiomyopathy (TTC). The aim of the current study was to evaluate the regional edema acutely and the status of the extracellular matrix at follow up

Eleven patients (10F, mean age 56±16yrs) with a clear diagnosis of ST-elevation TTC and emotional trigger were prospectively enrolled and underwent cardiac magnetic resonance acutely (day 0-3) and after 4 months on a Philips 3T Achieva scanner. Native 3-3-5 (MOLLI) T1 mapping was applied acutely, and both native and post-contrast T1 mapping were performed at 4 months follow-up. Eleven healthy controls underwent only native T1 mapping. T1 maps were: generated using in-house software - written in IDL (Exelis. Boulder CO, USA); quality controlled with chi-square maps; and imported into Segment (Medviso, Lund University, Sweden), where T1 values were generated for 16 segments. Extracellular volumes (ECV) were calculated for the follow-up scan using:

ECV=(1-hermatocrit)(ΔR1myocardium/ ΔR1blood)

Segments were grouped according to their wall motion (WM) on the acute scan (normal/abnormal).
Original languageEnglish
Article numberP259
Number of pages1
JournalJournal of Cardiovascular Magnetic Resonance
Issue numberSuppl. 1
Publication statusPublished - 3 Feb 2015

Bibliographical note

Tenovus Scotland. Grant number G13/10.


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