Early phytocannabinoid chemistry to endocannabinoids and beyond

Raphael Mechoulam*, Lumir O. Hanus, Roger Pertwee, Allyn C. Howlett

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

249 Citations (Scopus)


Isolation and structure elucidation of most of the major cannabinoid constituents-including Delta(9)-tetrahydrocannabinol (Delta(9)-THC), which is the principal psychoactive molecule in Cannabis sativa-was achieved in the 1960s and 1970s. It was followed by the identification of two cannabinoid receptors in the 1980s and the early 1990s and by the identification of the endocannabinoids shortly thereafter. There have since been considerable advances in our understanding of the endocannabinoid system and its function in the brain, which reveal potential therapeutic targets for a wide range of brain disorders.

Original languageEnglish
Pages (from-to)757-764
Number of pages8
JournalNature reviews neuroscience
Issue number11
Early online date15 Oct 2014
Publication statusPublished - Nov 2014


Dive into the research topics of 'Early phytocannabinoid chemistry to endocannabinoids and beyond'. Together they form a unique fingerprint.

Cite this