Economic evaluation of Medically Assisted Reproduction: an educational overview of methods and applications for healthcare professionals

Jeroen Luyten, Mark P. Connolly, Evelyn Verbeke, Klaus Buhler, Graham Scotland, Monica Lispi, Alberto Revelli, Isabelle Borget, Isabelle Cedrin-Durnerinm, Thomas M. D’hooghe* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
3 Downloads (Pure)


Economic evaluations of the value-for-money of Medically Assisted Reproduction (MAR) interventions are increasingly important due to growing pressure on healthcare budgets. While such evaluations are commonplace in the published literature, the number/methodological complexity of different evaluations available, and the challenges specific to MAR interventions, can complicate the interpretation of such analyses for fertility treatments. This article aims to serve as an educational resource and provide context on the design/interpretation of economic analyses for MAR interventions. Several areas are relevant for first-line providers and decision makers: scope of analysis, comparator used, perspective/time horizon considered, outcomes used to measure success, and how results from cost-effectiveness studies can be summarized and used in clinical practice. We aim to help clinicians better understand the strengths/weaknesses of economic analyses, to enable the best use of the evidence in practice, so resources available for MAR interventions can provide maximum value to patients and society.
Original languageEnglish
Pages (from-to)217-228
Number of pages12
JournalBest Practice & Research Clinical Obstetrics & Gynaecology
Early online date2 Feb 2022
Publication statusPublished - 1 Dec 2022

Bibliographical note

Medical writing support was provided by Steven Goodrick of in Science Communications, Springer Healthcare Ltd, UK, and was funded by Merck Healthcare KGaA, Darmstadt, Germany

Data Availability Statement

Data availability
Any requests for data by qualified scientific and medical researchers for legitimate research purposes will be subject to Merck KGaA's Data Sharing Policy. All requests should be submitted in writing to Merck KGaA's data sharing portal When Merck KGaA has a co-research, co-development, or co-marketing or co-promotion agreement, or when the product has been out-licensed, the responsibility for disclosure might be dependent on the agreement between parties. Under these circumstances, Merck KGaA will endeavour to gain agreement to share data in response to requests.


  • Economic evaluation
  • Assisted reproduction
  • Cost-effectiveness analysis
  • Fertility treatment


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