Effect of soy isoflavones on C-reactive protein in chronic inflammatory disorders: A systematic review and meta-analysis

Ali Gholami, Fatemeh Darudi, Hamid Reza Baradaran, Mitra Hariri* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

New evidence suggests that soy products might reduce chronic systemic inflammation. Therefore, we aimed to summarize the effect of soy isoflavones on serum concentration of C-reactive protein (CRP) among participants with chronic inflammatory disorders by conducting this study. Cochrane Library, Scopus, ISI Web of Science, clinicaltrials.gov, and PubMed were searched to identify randomized clinical trials (RCTs) published up to December 2020. The effect size was calculated by the mean change from baseline in concentrations of CRP and its standard deviation for both intervention and comparison groups. DerSimonian and Laird random-effects model was used when the heterogeneity test was statistically significant. In total, thirteen RCTs involving 1213 participants and ten RCTs involving 1052 participants were eligible for our systematic review and meta-analysis respectively. Study duration ranged from 4 to 96 weeks and soy isoflavones dose varied from 33 to 132 mg/day. Overall effect size indicated a non-significant effect on serum concentration of CRP following soy isoflavones intake (weighted mean differences (WMD)=-0.15 mg/L, 95% confidence interval (CI): -0.54, 0.23; p=0.430). Subgroup analysis revealed that soy isoflavones significantly reduced serum concentration of CRP in studies among participants with age >57 years and baseline CRP levels >3.75 mg/L. The present study proposed that soy isoflavones could not significantly reduce serum CRP levels. It seems more RCTs on participants with age more than 57 years and higher levels of CRP is necessary.

Original languageEnglish
Pages (from-to)447-458
Number of pages12
JournalInternational journal for vitamin and nutrition research
Volume93
Issue number5
Early online date16 Mar 2022
DOIs
Publication statusPublished - 1 Oct 2023

Bibliographical note

Acknowledgments:
We are extremely grateful to the data collection team at the Neyshabur University of Medical Sciences.

Funding:
This study was financially supported by Neyshabur University of Medical Sciences (Grant number: 98-01-149; Ethical code: IR.NUMS.REC.1399.006).

Keywords

  • Soy isoflavones
  • systematic review
  • meta-analysis
  • C-reactive protein
  • CARDIOVASCULAR RISK-FACTORS
  • OBESE POSTMENOPAUSAL WOMEN
  • LDL CHOLESTEROL
  • DOUBLE-BLIND
  • KAPPA-B
  • EXERCISE
  • SUPPLEMENTATION
  • PHYTOESTROGENS
  • CONSUMPTION
  • CYTOKINES

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