Effectiveness of allergic rhinitis treatments in real-life with a focus on MP-AzeFlu

Ludger Klimek, Pascal Demoly, David Price

Research output: Contribution to journalLiterature reviewpeer-review

1 Citation (Scopus)


For any allergic rhinitis (AR) treatment, it is crucial to provide evidence not only of efficacy (assessed in randomized controlled trials (RCTs)) but also of effectiveness in real-life. Observational studies provide valuable data on the use and results associated with interventions prescribed in real-life. However, real-life evidence supporting available AR treatment options is sparse with effectiveness only established for oral antihistamines (desloratadine, ebastine), intranasal corticosteroids (mometasone furoate, fluticasone propionate (FP)), allergen immunotherapy and Omalizumab. A novel intranasal formulation of azelastine and FP in a single spray (MP-AzeFlu) shows great promise, with the effectiveness observed in real-life exceeding that noted in RCTs. This review summarises real-life data on MP-AzeFlu, which provides rapid and sustained symptom control irrespective of patient age, AR phenotype or disease severity. We call for high quality real-life research in addition to RCTs to inform future AR treatment guidelines.

Original languageEnglish
Pages (from-to)705-714
Number of pages10
JournalExpert Review of Clinical Pharmacology
Issue number5
Early online date27 Feb 2016
Publication statusPublished - 2016


  • allergic rhinitis
  • effectiveness
  • MP-AzeFlu
  • real-life


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