Effectiveness of human papillomavirus vaccine against cervical precancer in Japan: Multivariate analyses adjusted for sexual activity.

Risa Kudo; Masayuki Sekine; Manako Yamaguchi; Megumi Hara; Sharon J. B. Hanley; Megumi Kurosawa; Sosuke Adachi; Yutaka Ueda; Etsuko Miyagi; Sayaka Ikeda; Asami Yagi; Takayuki Enomoto

doi:10.1111/cas.15471

Effectiveness of human papillomavirus vaccine against cervical precancer in Japan: Multivariate analyses adjusted for sexual activity.

Risa Kudo, Masayuki Sekine^* (Corresponding Author), Manako Yamaguchi, Megumi Hara, Sharon J. B. Hanley, Megumi Kurosawa, Sosuke Adachi, Yutaka Ueda, Etsuko Miyagi, Sayaka Ikeda, Asami Yagi, Takayuki Enomoto

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Japanese girls aged 12-16 years are offered free human papillomavirus (HPV) vaccination and cervical cancer screening is conducted with cytology and not HPV testing from the age of 20 years. So far, no study has analyzed the effect of HPV vaccination against cervical precancers considering HPV infection status and sexual activity. We aimed to analyze the vaccine effectiveness (VE) against HPV infection and cytological abnormalities, adjusted for sexual activity. This study comprised women aged 20-26 years who underwent cervical screening in Niigata. We obtained HPV vaccination status from municipal records and a questionnaire along with information concerning sexual activity. Of 5194 women registered for this study, final analyses included 3167 women in the vaccinated group (2821 vaccinated women prior to sexual debut) and 1386 women in the unvaccinated group. HPV 16/18 (0.2% vs 3.5%), 31/45/52 (3.4% vs 6.6%), and 31/33/45/52/58 (5.0% vs 9.3%) positive rates were significantly lower in the vaccinated group (P

Original language	English
Pages (from-to)	3211-3220
Number of pages	10
Journal	Cancer Science
Volume	113
Issue number	9
Early online date	11 Jul 2022
DOIs	https://doi.org/10.1111/cas.15471
Publication status	Published - 1 Sept 2022

Bibliographical note

ACKNOWLEDGMENTS
We would like to thank Mr Kenshin Sekine and Mr Taishin Sekine for English editing, and Ms Yuka Watanabe, Ms Sachiko Ono, Ms Anna Ishida, and administrators of Niigata, Nagaoka, Joetsu, Shibata, Sanjo, Mitsuke city for their support in conducting the survey.

Keywords

cervical cancer
cytological abnormality
HPV infection
HPV vaccine
sexual activity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/cas.15471Licence: CC BY

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This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2022 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association https://creativecommons.org/licenses/by/4.0/
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Cite this

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title = "Effectiveness of human papillomavirus vaccine against cervical precancer in Japan: Multivariate analyses adjusted for sexual activity.",

abstract = "Japanese girls aged 12-16 years are offered free human papillomavirus (HPV) vaccination and cervical cancer screening is conducted with cytology and not HPV testing from the age of 20 years. So far, no study has analyzed the effect of HPV vaccination against cervical precancers considering HPV infection status and sexual activity. We aimed to analyze the vaccine effectiveness (VE) against HPV infection and cytological abnormalities, adjusted for sexual activity. This study comprised women aged 20-26 years who underwent cervical screening in Niigata. We obtained HPV vaccination status from municipal records and a questionnaire along with information concerning sexual activity. Of 5194 women registered for this study, final analyses included 3167 women in the vaccinated group (2821 vaccinated women prior to sexual debut) and 1386 women in the unvaccinated group. HPV 16/18 (0.2% vs 3.5%), 31/45/52 (3.4% vs 6.6%), and 31/33/45/52/58 (5.0% vs 9.3%) positive rates were significantly lower in the vaccinated group (P ",

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author = "Risa Kudo and Masayuki Sekine and Manako Yamaguchi and Megumi Hara and Hanley, {Sharon J. B.} and Megumi Kurosawa and Sosuke Adachi and Yutaka Ueda and Etsuko Miyagi and Sayaka Ikeda and Asami Yagi and Takayuki Enomoto",

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AU - Hara, Megumi

AU - Hanley, Sharon J. B.

AU - Kurosawa, Megumi

AU - Adachi, Sosuke

AU - Ueda, Yutaka

AU - Miyagi, Etsuko

AU - Ikeda, Sayaka

AU - Yagi, Asami

AU - Enomoto, Takayuki

N1 - ACKNOWLEDGMENTS We would like to thank Mr Kenshin Sekine and Mr Taishin Sekine for English editing, and Ms Yuka Watanabe, Ms Sachiko Ono, Ms Anna Ishida, and administrators of Niigata, Nagaoka, Joetsu, Shibata, Sanjo, Mitsuke city for their support in conducting the survey.

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N2 - Japanese girls aged 12-16 years are offered free human papillomavirus (HPV) vaccination and cervical cancer screening is conducted with cytology and not HPV testing from the age of 20 years. So far, no study has analyzed the effect of HPV vaccination against cervical precancers considering HPV infection status and sexual activity. We aimed to analyze the vaccine effectiveness (VE) against HPV infection and cytological abnormalities, adjusted for sexual activity. This study comprised women aged 20-26 years who underwent cervical screening in Niigata. We obtained HPV vaccination status from municipal records and a questionnaire along with information concerning sexual activity. Of 5194 women registered for this study, final analyses included 3167 women in the vaccinated group (2821 vaccinated women prior to sexual debut) and 1386 women in the unvaccinated group. HPV 16/18 (0.2% vs 3.5%), 31/45/52 (3.4% vs 6.6%), and 31/33/45/52/58 (5.0% vs 9.3%) positive rates were significantly lower in the vaccinated group (P

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Effectiveness of human papillomavirus vaccine against cervical precancer in Japan: Multivariate analyses adjusted for sexual activity.

Abstract

Bibliographical note

Keywords

UN SDGs

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