Abstract
Sport-related repetitive subconcussive head impacts (RSHIs) are increasingly thought to be associated with adverse long-term outcomes. However, owing to potentially subtle effects, accurate assessment of harm to the brain as a consequence of RSHI is a major challenge and an unmet need. Several studies suggest that biofluid markers can be valuable objective tools to aid the diagnosis and injury characterisation and help in medical decision-making. Still, by and large, the results have been limited, heterogeneous and inconsistent. The main aims of this scoping review are therefore (1) to systematically examine the extent, nature and quality of available evidence from studies investigating effects of RSHI on fluid biomarkers and (2) to formulate guidelines and identify gaps with the aim to inform future clinical studies and the development of research priorities.
| Original language | English |
|---|---|
| Article number | e046452 |
| Number of pages | 4 |
| Journal | BMJ Open |
| Volume | 11 |
| Early online date | 28 Jun 2021 |
| DOIs | |
| Publication status | Published - 28 Jun 2021 |
| Externally published | Yes |
Bibliographical note
This review is supported by the University of Stirling (no grant number applies). LW also received support as part of Framework 7 programme of the European Union (CENTER-TBI, grant number: 602150-2). SM: received research support from the Italian Ministry of Health (GR-2013-02354960).Data Availability Statement
Supplementary DataThis web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.