EFSA International Workshop on RA of Combined Exposure to Multiple Chemicals

European Food Safety Authority (EFSA), Jean-Lou CM Dorne, Christer Hogstrand, Bruno Dujardin, George EN Kass, AK Djien Liem, Jose Tarazona, Kyriaki Machera, Tobin Robinson, Paola Manini, Emilio Benfenati, Jan Dirk te Biesebeek, Josef Schlatter, Paul Price, Patience Browne, Alan R Boobis, Angelo Moretto, Anthony Smith, Emanuela Testai, Antonio Hernández-JerezSusanne Hougaard-Bennekou, Vittorio Fattori, Stephanie Bopp, Heather Wallace

Research output: Contribution to specialist publicationReportpeer-review


Abstract Human Risk Assessment (RA) of combined exposure to multiple chemicals follows the steps of RA namely problem formulation, exposure assessment, hazard assessment and risk characterisation. Over the last decade, scientific advisory bodies have published a range of harmonised guidance documents to provide practical approaches for risk assessors. These include the WHO, the US-EPA, the Joint Research Centre (JRC) of the European Commission, the OECD and the recent EFSA MIXTOX guidance document dealing with harmonised methodologies for the human health, animal health and ecological RA areas. On May 21st 2021, the Scientific Committee of EFSA published a draft guidance document on scientific criteria to group chemicals in assessment groups using hazard-driven criteria and prioritisation methods using exposure-driven and risk-based approaches. The latter guidance and future challenges were the topic of this international workshop which was held online in the afternoons of the 18th, 19th and 20st October 2021. First, a plenary session provided overviews of European and international activities in the field including WHO, OECD, US-EPA, JRC and EFSA. With a total of 118 participants including national and international scientific advisory bodies, academics and researchers, NGOs, industry, risk assessors, risk managers, four discussions groups were created for three break-out group sessions: 1) Hazard-driven criteria for grouping multiple chemicals into assessment groups; 2) Exposure-driven and risk-based criteria for the prioritisation of multiple chemicals 3) Data gaps and future challenges for human health and environmental RA of combined exposure to multiple chemicals to identify priority topics of international relevance and a way forward to address these topics. A final discussion and wrap-up session concluded the meeting. This event report provides a summary of the discussions together with conclusions and recommendations.
Original languageEnglish
Number of pages32
Specialist publicationEFSA Supporting Publications
Publication statusPublished - 22 Jul 2022

Bibliographical note

Acknowledgements: EFSA wishes to thank EFSA staff members: Jean-Lou CM Dorne, Bruno Dujardin, Georges Kass, Jose Tarazona, AK Djien Liem, Paola Manini, Tobin Robinson, Anthony Smith, Vanessa Descy and Experts: Emilio Benfenati, Jan Dirk te Biesebeek, Josef Schlatter, Angelo Moretto, Vittorio Fattori, Alan R Boobis, Emanuela Testai, Patience Browne, Kyriaki Machera, Antonio Hernández-Jerez, Susanne Hougaard-Bennekou, Stephanie Bopp, Heather Wallace for the support provided to this scientific output. EFSA wishes to thank Fleur van Broekhuizen from the European Chemicals Agency (ECHA) for the scientific contribution to the workshop.


  • RA
  • combined exposure
  • multiple chemicals
  • grouping
  • scientific criteria
  • future challenges


Dive into the research topics of 'EFSA International Workshop on RA of Combined Exposure to Multiple Chemicals'. Together they form a unique fingerprint.

Cite this