Enhanced in vivo response to silicate-substituted hydroxyapatite

I R Gibson, K A Hing, P A Revell, J D Santos, S M Best, W Bonfield

Research output: Chapter in Book/Report/Conference proceedingPublished conference contribution

32 Citations (Scopus)


This paper describes an investigation into the effect of silicate ion substitution in hydroxyapatite on the rate of bone healing in vivo. Slotted cylinders composed of stoichiometric hydroxyapatite and 1.2 wt% silicate substituted hydroxyapatite (S-HA) were implanted in the distal end of the femur of 6 month old New Zealand white rabbits for a period of 3 weeks. Tetracycline and alizarine red fluorochrome labels were administered 7 and 14 days post-operatively, respectively. After retrieval the implants were sectioned and examined using optical and fluorescence microscopy. Optical microscopy demonstrated that significant amounts of bone formation was only consistently found at the center of the machined slots of the silicate substituted implants. Moreover, fluorescence microscopy demonstrated that of the new bone laid down around and in contact with the implants, significant quantities of tetracycline labeled bone (i.e. bone laid down seven days after implantation) was only present in S-HA implants. These results indicate that the bioactivity of hydroxyapatite is significantly enhanced by the incorporation of silicate ions into its lattice.

Original languageEnglish
Title of host publicationBIOCERAMICS 14
EditorsS Brown, I Clarke, P Williams
Place of PublicationZURICH-UETIKON
PublisherTrans Tech Publications Ltd
Number of pages4
ISBN (Print)0-87849-889-3
Publication statusPublished - 2002
Event14th International Symposium on Ceramics in Medicine (BIOCERAMICS-14) - PALM SPRINGS
Duration: 14 Nov 200117 Nov 2001


Conference14th International Symposium on Ceramics in Medicine (BIOCERAMICS-14)


  • hydroxyapatite
  • silicate-substitution
  • in vivo response
  • accelerated osteoconduction


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