Environmental and metabolic sensors that control T cell biology

George Ramsay, Doreen Cantrell*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

44 Citations (Scopus)
6 Downloads (Pure)


The T lymphocyte response to pathogens is shaped by the microenvironment. Environmental sensors in T cells include the nutrient-sensing serine/threonine kinases, adenosine monophosphate-activated protein kinase and mammalian target of rapamycin complex 1. Other environmental sensors are transcription factors such as hypoxia-inducible factor-1 and the aryl hydrocarbon receptor. The present review explores the molecular basis for the impact of environmental signals on the differentiation of conventional T cell receptor αβ T cells and how the T cell response to immune stimuli can coordinate the T cell response to environmental cues.

Original languageEnglish
Article number99
JournalFrontiers in Immunology
Early online date17 Mar 2015
Publication statusPublished - 17 Mar 2015
Externally publishedYes


  • Amino acid uptake
  • Aryl hydrocarbon
  • Glucose uptake
  • Hypoxia
  • Leucine and mTOR
  • Microbiome
  • T cell metabolism


Dive into the research topics of 'Environmental and metabolic sensors that control T cell biology'. Together they form a unique fingerprint.

Cite this