Epithelial barrier function in gut-bone signaling

Naiomy Deliz Rios-Arce, Fraser L. Collins, Jonathan D. Schepper, Michael D. Steury, Sandi Raehtz, Heather Mallin, Danny T. Schoenherr, Narayanan Parameswaran, Laura R. McCabe

Research output: Chapter in Book/Report/Conference proceedingChapter

39 Citations (Scopus)


The intestinal epithelial barrier plays an essential role in maintaining host homeostasis. The barrier regulates nutrient absorption as well as prevents the invasion of pathogenic bacteria in the host. It is composed of epithelial cells, tight junctions, and a mucus layer. Several factors, such as cytokines, diet, and diseases, can affect this barrier. These factors have been shown to increase intestinal permeability, inflammation, and translocation of pathogenic bacteria. In addition, dysregulation of the epithelial barrier can result in inflammatory diseases such as inflammatory bowel disease. Our lab and others have also shown that barrier disruption can have systemic effects including bone loss. In this chapter, we will discuss the current literature to understand the link between intestinal barrier and bone. We will discuss how inflammation, aging, dysbiosis, and metabolic diseases can affect intestinal barrier-bone link. In addition, we will highlight the current suggested mechanism between intestinal barrier and bone.
Original languageEnglish
Title of host publicationUnderstanding the Gut-Bone Signaling Axis
Subtitle of host publicationMechanisms and Therapeutic Implications
EditorsLaura R. McCabe, Narayanan Parameswaran
PublisherSpringer New York LLC
Number of pages33
ISBN (Electronic)978-3-319-66653-2
ISBN (Print)978-3-319-66651-8
Publication statusPublished - 2017

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598


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