Evidence and implications of abnormal predictive coding in dementia

Ece Kocagoncu*, Anastasia Klimovich-Gray, Laura E. Hughes, James B. Rowe

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)
6 Downloads (Pure)


The diversity of cognitive deficits and neuropathological processes associated with dementias has encouraged divergence in pathophysiological explanations of disease. Here, we review an alternative framework that emphasizes convergent critical features of cognitive pathophysiology. Rather than the loss of 'memory centres' or 'language centres', or singular neurotransmitter systems, cognitive deficits are interpreted in terms of aberrant predictive coding in hierarchical neural networks. This builds on advances in normative accounts of brain function, specifically the Bayesian integration of beliefs and sensory evidence in which hierarchical predictions and prediction errors underlie memory, perception, speech and behaviour. We describe how analogous impairments in predictive coding in parallel neurocognitive systems can generate diverse clinical phenomena, including the characteristics of dementias. The review presents evidence from behavioural and neurophysiological studies of perception, language, memory and decision-making. The reformulation of cognitive deficits in terms of predictive coding has several advantages. It brings diverse clinical phenomena into a common framework; it aligns cognitive and movement disorders; and it makes specific predictions on cognitive physiology that support translational and experimental medicine studies. The insights into complex human cognitive disorders from the predictive coding framework may therefore also inform future therapeutic strategies.

Original languageEnglish
Pages (from-to)3311-3321
Number of pages11
Issue number11
Early online date8 Jul 2021
Publication statusPublished - 1 Nov 2021

Bibliographical note

E.K. is funded by the Dementias Platform UK and Alzheimer’s Research UK (RG94383/RG89702). J.B.R. is supported by the Wellcome Trust (103838) and Medical Research Council (SUAG/051G101400) and the National Institute for Health Research Cambridge Biomedical Research Centre. L.E.H. is funded by the Wellcome Trust (103838). A.K.-G. is funded by the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie grant (798971).


  • dementia
  • neurodegeneration
  • prediction
  • predictive coding
  • top-down processing


Dive into the research topics of 'Evidence and implications of abnormal predictive coding in dementia'. Together they form a unique fingerprint.

Cite this