Abstract
Cardiac damage has recently been implicated in the aetiology of "exercise induced cardiac dysfunction". The humoral markers of cardiac damage that have been utilised to date are not sufficiently cardio-specific to investigate this hypothesis. The aim of the present study was to examine cardiac function following prolonged exercise, and investigate the contention of cardiac damage utilising a new highly cardio-specific marker. Thirty-seven competitors in the 2-day Lowe Alpine Mountain Marathon 2000 volunteered for the study. Competitors were sub-divided into 2 groups. Group I (n = 11) were examined using echocardiography pre and post the event, examining left ventricular diastolic and systolic function. Group 2 (n = 26) had venous blood samples drawn prior to the event and immediately following day-1 and day-2. Blood samples were analysed for total creatine kinase activity (CK), creatine kinase isoenzyme MBmass. (CK-MBmass,,), and cardiac troponin T. Echocardiographic results indicated left ventricular diastolic and systolic dysfunction following cessation of exercise. CK and CK-MBmass were both elevated following day-1, and immediately following race completion. Cardiac troponin T levels were below the 99th percentile (0.01 mug/L) in all subjects prior to the event, following day-1 cTnT was elevated above 0.01 mug/L in 13 subjects, but returned to below 0.01 mug/L following race completion on day-2. However, no individual data reached clinical cut-off levels for acute myocardial, infarction (AMI) (0.1 mug/L). Two days arduous exercise over mountainous terrain resulted in cardiac dysfunction, and significant skeletal muscular degradation. The elevation of cTnT above the 99th percentile in the present study is suggestive of minimal myocardial damage. The clinical significance of and exact mechanism responsible for such damage remains to be elucidated.
Original language | English |
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Pages (from-to) | 489-494 |
Number of pages | 5 |
Journal | International Journal of Sports Medicine |
Volume | 23 |
DOIs | |
Publication status | Published - 2002 |
Keywords
- cTnT
- cardiac dysfunction
- endurance exercise
- LEFT-VENTRICULAR DYSFUNCTION
- TROPONIN-T
- MYOCARDIAL-INFARCTION
- PROLONGED EXERCISE
- INTRACELLULAR COMPARTMENTATION
- STRENUOUS EXERCISE
- RELEASE KINETICS
- HEALTHY-SUBJECTS
- MUSCLE
- SERUM