Failures (with some successes) of assisted reproduction and gamete donation programs

D T Baird; S Bhattacharya; P Devroey; K Diedrich; J L H Evers; B C J M Fauser; P Jouannet; A Pellicer; E  Walters; P G Crosignani; L Fraser; J P M Geraedts; L Gianaroli; A Glasier; I Liebaers; A Sunde; J S  Tapanainen; B Tarlatzis; A Van Steirteghem; A Veiga

doi:10.1093/humupd/dmt007

Failures (with some successes) of assisted reproduction and gamete donation programs

D T Baird, S Bhattacharya, P Devroey, K Diedrich, J L H Evers, B C J M Fauser, P Jouannet, A Pellicer, E Walters, P G Crosignani (Corresponding Author), L Fraser, J P M Geraedts, L Gianaroli, A Glasier, I Liebaers, A Sunde, J S Tapanainen, B Tarlatzis, A Van Steirteghem, A Veiga

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Abstract

BACKGROUND Although the possibilities for the treatment of infertility have been improved tremendously, not every couple will be treated successfully.

METHODS Crude overall pregnancy rates of 50–65% per patient can be achieved nowadays, irrespective of the type of profertility treatment applied first.

RESULTS IVF only accounts for about 20% of the pregnancies achieved. Dropout is an important reason for not reaching the estimated pregnancy rate. Even after failed IVF, spontaneous pregnancies do occur. Sperm and oocyte donation (OD) offer additional chances to subfertile couples. Severity of the male factor (in sperm donation) and young donor age (in OD) are important determinants of success.

CONCLUSIONS Analysis of assisted reproduction technology outcomes would benefit from more universally accepted definitions and deserves better statistical analysis. Long-term cumulative live birth rates of 80% may be expected if dropout can be limited. Milder stimulation, a patient-friendlier approach and better counseling may help to keep more patients in the program.

Original language	English
Pages (from-to)	354-365
Number of pages	12
Journal	Human Reproduction Update
Volume	19
Issue number	4
Early online date	3 Mar 2013
DOIs	https://doi.org/10.1093/humupd/dmt007
Publication status	Published - Jul 2013
Event	ESHRE Capri Workshop - Capri, Italy Duration: 29 Aug 2012 → 31 Aug 2012

Keywords

assisted reproduction technology
ICSI
intrauterine insemination
IVF
oocyte donation

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10.1093/humupd/dmt007

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Baird, D. T., Bhattacharya, S., Devroey, P., Diedrich, K., Evers, J. L. H., Fauser, B. C. J. M., Jouannet, P., Pellicer, A., Walters, E., Crosignani, P. G., Fraser, L., Geraedts, J. P. M., Gianaroli, L., Glasier, A., Liebaers, I., Sunde, A., Tapanainen, J. S., Tarlatzis, B., Van Steirteghem, A., & Veiga, A. (2013). Failures (with some successes) of assisted reproduction and gamete donation programs. Human Reproduction Update, 19(4), 354-365. https://doi.org/10.1093/humupd/dmt007

Baird, DT, Bhattacharya, S, Devroey, P, Diedrich, K, Evers, JLH, Fauser, BCJM, Jouannet, P, Pellicer, A, Walters, E, Crosignani, PG, Fraser, L, Geraedts, JPM, Gianaroli, L, Glasier, A, Liebaers, I, Sunde, A, Tapanainen, JS, Tarlatzis, B, Van Steirteghem, A & Veiga, A 2013, 'Failures (with some successes) of assisted reproduction and gamete donation programs', Human Reproduction Update, vol. 19, no. 4, pp. 354-365. https://doi.org/10.1093/humupd/dmt007

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title = "Failures (with some successes) of assisted reproduction and gamete donation programs",

abstract = "BACKGROUND Although the possibilities for the treatment of infertility have been improved tremendously, not every couple will be treated successfully.METHODS Crude overall pregnancy rates of 50–65% per patient can be achieved nowadays, irrespective of the type of profertility treatment applied first.RESULTS IVF only accounts for about 20% of the pregnancies achieved. Dropout is an important reason for not reaching the estimated pregnancy rate. Even after failed IVF, spontaneous pregnancies do occur. Sperm and oocyte donation (OD) offer additional chances to subfertile couples. Severity of the male factor (in sperm donation) and young donor age (in OD) are important determinants of success.CONCLUSIONS Analysis of assisted reproduction technology outcomes would benefit from more universally accepted definitions and deserves better statistical analysis. Long-term cumulative live birth rates of 80% may be expected if dropout can be limited. Milder stimulation, a patient-friendlier approach and better counseling may help to keep more patients in the program.",

keywords = "assisted reproduction technology, ICSI, intrauterine insemination, IVF, oocyte donation",

author = "Baird, {D T} and S Bhattacharya and P Devroey and K Diedrich and Evers, {J L H} and Fauser, {B C J M} and P Jouannet and A Pellicer and E Walters and Crosignani, {P G} and L Fraser and Geraedts, {J P M} and L Gianaroli and A Glasier and I Liebaers and A Sunde and Tapanainen, {J S} and B Tarlatzis and {Van Steirteghem}, A and A Veiga",

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T1 - Failures (with some successes) of assisted reproduction and gamete donation programs

AU - Baird, D T

AU - Bhattacharya, S

AU - Devroey, P

AU - Diedrich, K

AU - Evers, J L H

AU - Fauser, B C J M

AU - Jouannet, P

AU - Pellicer, A

AU - Walters, E

AU - Crosignani, P G

AU - Fraser, L

AU - Geraedts, J P M

AU - Gianaroli, L

AU - Glasier, A

AU - Liebaers, I

AU - Sunde, A

AU - Tapanainen, J S

AU - Tarlatzis, B

AU - Van Steirteghem, A

AU - Veiga, A

PY - 2013/7

Y1 - 2013/7

N2 - BACKGROUND Although the possibilities for the treatment of infertility have been improved tremendously, not every couple will be treated successfully.METHODS Crude overall pregnancy rates of 50–65% per patient can be achieved nowadays, irrespective of the type of profertility treatment applied first.RESULTS IVF only accounts for about 20% of the pregnancies achieved. Dropout is an important reason for not reaching the estimated pregnancy rate. Even after failed IVF, spontaneous pregnancies do occur. Sperm and oocyte donation (OD) offer additional chances to subfertile couples. Severity of the male factor (in sperm donation) and young donor age (in OD) are important determinants of success.CONCLUSIONS Analysis of assisted reproduction technology outcomes would benefit from more universally accepted definitions and deserves better statistical analysis. Long-term cumulative live birth rates of 80% may be expected if dropout can be limited. Milder stimulation, a patient-friendlier approach and better counseling may help to keep more patients in the program.

AB - BACKGROUND Although the possibilities for the treatment of infertility have been improved tremendously, not every couple will be treated successfully.METHODS Crude overall pregnancy rates of 50–65% per patient can be achieved nowadays, irrespective of the type of profertility treatment applied first.RESULTS IVF only accounts for about 20% of the pregnancies achieved. Dropout is an important reason for not reaching the estimated pregnancy rate. Even after failed IVF, spontaneous pregnancies do occur. Sperm and oocyte donation (OD) offer additional chances to subfertile couples. Severity of the male factor (in sperm donation) and young donor age (in OD) are important determinants of success.CONCLUSIONS Analysis of assisted reproduction technology outcomes would benefit from more universally accepted definitions and deserves better statistical analysis. Long-term cumulative live birth rates of 80% may be expected if dropout can be limited. Milder stimulation, a patient-friendlier approach and better counseling may help to keep more patients in the program.

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KW - ICSI

KW - intrauterine insemination

KW - IVF

KW - oocyte donation

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DO - 10.1093/humupd/dmt007

M3 - Article

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SP - 354

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JO - Human Reproduction Update

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IS - 4

T2 - ESHRE Capri Workshop

Y2 - 29 August 2012 through 31 August 2012

ER -

Failures (with some successes) of assisted reproduction and gamete donation programs

Abstract

Keywords

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