Abstract
The lack of reliable translational procedures applicable to both patients and experimental models are a major obstacle for the advancement of basic research as well as for the development of therapeutics. This is particularly relevant to neurodegenerative disorders such as AD (Alzheimer's disease), where the predictive validity of animal models and procedures applied preclinically have met with little success. Two approaches available for human diagnostics are currently experiencing major advancements in preclinical research: in vivo imaging using MRI (magnetic resonance imaging) or PET (positron-emission tomography) and recordings of brain electrical activity via surface EEG (electroencephalogram). The present paper reviews the results obtained so far in rodent AD models, and summarizes advantages and disadvantages of such procedures.
| Original language | English |
|---|---|
| Pages (from-to) | 874-880 |
| Number of pages | 7 |
| Journal | Biochemical Society Transactions |
| Volume | 39 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 2011 |
Keywords
- Alzheimer's disease (AD)
- Imaging
- Positron-emission tomography (PET)
- Power spectrum
- Quantitative electroencephalogram
- Sleep
Access to Document
- FDG PET imaging
Platt, B, Welch, A & Riedel, G 2011, 'FDG-PET imaging, EEG and sleep phenotypes as translational biomarkers for research in Alzheimer's disease', Biochemical Society Transactions, vol 39, no. 4, pp. 874-880. The final version of record is available at http://www.biochemsoctrans.org/bst/default.htm