Field-cycled PEDRI imaging of free radicals with detection at 450 mT

David John Lurie; Gareth Reynold Davies; M. A. Foster; James McDonald Strachan Hutchison

doi:10.1016/j.mri.2004.11.051

Field-cycled PEDRI imaging of free radicals with detection at 450 mT

David John Lurie^* (Corresponding Author), Gareth Reynold Davies, M. A. Foster, James McDonald Strachan Hutchison

^*Corresponding author for this work

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Abstract

This paper describes the design, construction and use of a field-cycled proton–electron double-resonance imaging (FC-PEDRI) system for the detection and imaging of free radicals. The unique feature of this imager is its use of a 450-mT detection magnetic field in order to achieve good image quality and sensitivity. The detection magnetic field is provided by a superconducting magnet, giving high stability and homogeneity. Field cycling is implemented by switching on and off the current in an internal, coaxial, resistive secondary magnet that partially cancels the superconducting magnet's field at the sample; the secondary magnet is actively shielded to avoid eddy currents. EPR irradiation takes place at ∼5 mT, following which the field is switched to 450 mT in 40 ms for NMR signal detection. Full details of the imager's subsystems are given, and experiments to image the distribution of stable free radical contrast agents in phantoms and in anesthetized rats are described.

Original language	English
Pages (from-to)	175-181
Number of pages	6
Journal	Magnetic Resonance Imaging
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/j.mri.2004.11.051
Publication status	Published - Feb 2005

Bibliographical note

Funding was provided by the Engineering and Physical Sciences Research Council under grant number GR/M46488/01 and by the University of Aberdeen. The authors thank Mr. Takuya Yokoyama for writing software to facilitate subtraction of complex data sets, Mr. Eddie Stevenson for help with the mechanical construction of the FC-PEDRI system and Dr. Klaes Golman of Nycomed-Amersham for the kind gift of TAM radical.

Keywords

PEDRI
field-cycling
Overhauser imaging
free radical

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10.1016/j.mri.2004.11.051Licence: Unspecified

Field-cycled PEDRI at 450 mT
NOTICE: this is the author’s version of a work that was accepted for publication Magnetic Resonance Imaging. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Magnetic Resonance Imaging, [VOL 23, ISSUE 2, (Feb 2005)] DOI10.1016/j.mri.2004.11.051
Accepted author manuscript, 429 KBLicence: Unspecified

Cite this

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title = "Field-cycled PEDRI imaging of free radicals with detection at 450 mT",

abstract = "This paper describes the design, construction and use of a field-cycled proton–electron double-resonance imaging (FC-PEDRI) system for the detection and imaging of free radicals. The unique feature of this imager is its use of a 450-mT detection magnetic field in order to achieve good image quality and sensitivity. The detection magnetic field is provided by a superconducting magnet, giving high stability and homogeneity. Field cycling is implemented by switching on and off the current in an internal, coaxial, resistive secondary magnet that partially cancels the superconducting magnet's field at the sample; the secondary magnet is actively shielded to avoid eddy currents. EPR irradiation takes place at ∼5 mT, following which the field is switched to 450 mT in 40 ms for NMR signal detection. Full details of the imager's subsystems are given, and experiments to image the distribution of stable free radical contrast agents in phantoms and in anesthetized rats are described.",

keywords = "PEDRI, field-cycling, Overhauser imaging, free radical",

author = "Lurie, {David John} and Davies, {Gareth Reynold} and Foster, {M. A.} and Hutchison, {James McDonald Strachan}",

note = "Funding was provided by the Engineering and Physical Sciences Research Council under grant number GR/M46488/01 and by the University of Aberdeen. The authors thank Mr. Takuya Yokoyama for writing software to facilitate subtraction of complex data sets, Mr. Eddie Stevenson for help with the mechanical construction of the FC-PEDRI system and Dr. Klaes Golman of Nycomed-Amersham for the kind gift of TAM radical. ",

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doi = "10.1016/j.mri.2004.11.051",

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AU - Davies, Gareth Reynold

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AU - Hutchison, James McDonald Strachan

N1 - Funding was provided by the Engineering and Physical Sciences Research Council under grant number GR/M46488/01 and by the University of Aberdeen. The authors thank Mr. Takuya Yokoyama for writing software to facilitate subtraction of complex data sets, Mr. Eddie Stevenson for help with the mechanical construction of the FC-PEDRI system and Dr. Klaes Golman of Nycomed-Amersham for the kind gift of TAM radical.

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N2 - This paper describes the design, construction and use of a field-cycled proton–electron double-resonance imaging (FC-PEDRI) system for the detection and imaging of free radicals. The unique feature of this imager is its use of a 450-mT detection magnetic field in order to achieve good image quality and sensitivity. The detection magnetic field is provided by a superconducting magnet, giving high stability and homogeneity. Field cycling is implemented by switching on and off the current in an internal, coaxial, resistive secondary magnet that partially cancels the superconducting magnet's field at the sample; the secondary magnet is actively shielded to avoid eddy currents. EPR irradiation takes place at ∼5 mT, following which the field is switched to 450 mT in 40 ms for NMR signal detection. Full details of the imager's subsystems are given, and experiments to image the distribution of stable free radical contrast agents in phantoms and in anesthetized rats are described.

AB - This paper describes the design, construction and use of a field-cycled proton–electron double-resonance imaging (FC-PEDRI) system for the detection and imaging of free radicals. The unique feature of this imager is its use of a 450-mT detection magnetic field in order to achieve good image quality and sensitivity. The detection magnetic field is provided by a superconducting magnet, giving high stability and homogeneity. Field cycling is implemented by switching on and off the current in an internal, coaxial, resistive secondary magnet that partially cancels the superconducting magnet's field at the sample; the secondary magnet is actively shielded to avoid eddy currents. EPR irradiation takes place at ∼5 mT, following which the field is switched to 450 mT in 40 ms for NMR signal detection. Full details of the imager's subsystems are given, and experiments to image the distribution of stable free radical contrast agents in phantoms and in anesthetized rats are described.

KW - PEDRI

KW - field-cycling

KW - Overhauser imaging

KW - free radical

U2 - 10.1016/j.mri.2004.11.051

DO - 10.1016/j.mri.2004.11.051

M3 - Article

SN - 0730-725X

VL - 23

SP - 175

EP - 181

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

IS - 2

ER -

Field-cycled PEDRI imaging of free radicals with detection at 450 mT

Abstract

Bibliographical note

Keywords

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