Flawed Comparative Groups Lead to Flawed Conclusions: Response

Christopher C. Winchester* (Corresponding Author), Tatiana Macfarlane, Mike Thomas, David Price

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review


Our observational study1 of patients with lower respiratory tract infection (LRTI) presenting in the primary care setting showed a decrease in hospital admissions and mortality among patients who were prescribed an antibiotic on the day of consultation compared with those who did not receive such treatment. This association remained statistically significant after other potential factors influencing the outcomes of LRTI were taken into account in a multivariate model. These factors included comorbidity and its proxies, frequent health-care utilization and prior antibiotic use.
Original languageEnglish
Pages (from-to)1185-1186
Number of pages2
Issue number4
Publication statusPublished - Oct 2009


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