Fluorinated Inhibitors of Matrix Metalloproteinases

Roberta Sinisi, Monika Jagodzinska, Gabriele Candiani, Florent Huguenot, Monica Sani, Alessandro Volonterio, Raffaella Maffezzoni, Matteo Zanda

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)
Original languageEnglish
Title of host publicationFluorine in Medicinal Chemistry and Chemical Biology
EditorsIwao Ojima
Place of PublicationOxford, United Kingdom
Number of pages17
ISBN (Electronic)978-1444312096
ISBN (Print)1405167203 , 978-1405167208
Publication statusPublished - 9 Jun 2009


  • fluorinated inhibitors of matrix metalloproteinases
  • matrix metalloproteinases
  • family of highly homologous Zn(II)-endopeptidases
  • degradation of extracellular matrix and connective tissue remodeling
  • a-CF3-malic hydroxamate inhibitors
  • Jacobsen's potent peptidomimetic hydroxamate inhibitors
  • a -trifluoromethyl-a-amino-ß-sulfone hydroxamate inhibitors
  • nanomolar CF3-barbituric acid inhibitor selective for MMP-9

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