Fractal dimension analysis of MR images reveals grey matter structure irregularities in schizophrenia.

Anca-Larisa Sandu-Giuraniuc* (Corresponding Author), Inge-Andre Rasmussen Jr., Arvid Lundervold, Frank Kreuder, Gesche Neckelmann, Kenneth Hugdahl, Karsten Specht

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

69 Citations (Scopus)


The fractal dimension (FD) was used to reveal brain structure irregularities in patients with schizophrenia. FD provides a unique way of quantifying the shape complexity of cortical folding of the human brain. MR images were obtained from seven patients with schizophrenia that were compared with six healthy control subjects. The MR images were first segmented, and the FD was calculated for the grey/white matter boundary for the whole brain and the hemispheres separately, using the box-counting and Minkowski-Bouligand methods. The results showed that the patients had larger FD values than the controls, for the whole brain volume and right hemisphere.
Original languageEnglish
Pages (from-to)150-158
Number of pages9
JournalComputerized Medical Imaging and Graphics
Issue number2
Early online date18 Dec 2007
Publication statusPublished - 31 Mar 2008
Externally publishedYes

Bibliographical note

The present research was financially supported by a grant to Kenneth Hugdahl from the Alfried Krupp von Bohlen und Halbach Stiftung, Germany.

The software and the data sets can be made available to other researchers after inquiry to the principal investigator, Kenneth Hugdahl.


  • Fractal dimension
  • Brain imaging
  • Schizophrenia


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